Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Eric Fischer
LAB HEAD: Eric Fischer
PROVIDER: PXD019165 | Pride | 2021-04-06
REPOSITORIES: Pride
Donovan Katherine A KA Ferguson Fleur M FM Bushman Jonathan W JW Eleuteri Nicholas A NA Bhunia Debabrata D Ryu SeongShick S Tan Li L Shi Kun K Yue Hong H Liu Xiaoxi X Dobrovolsky Dennis D Jiang Baishan B Wang Jinhua J Hao Mingfeng M You Inchul I Teng Mingxing M Liang Yanke Y Hatcher John J Li Zhengnian Z Manz Theresa D TD Groendyke Brian B Hu Wanyi W Nam Yunju Y Sengupta Sandip S Cho Hanna H Shin Injae I Agius Michael P MP Ghobrial Irene M IM Ma Michelle W MW Che Jianwei J Buhrlage Sara J SJ Sim Taebo T Gray Nathanael S NS Fischer Eric S ES
Cell 20201203 6
Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug development, as it can address previously inaccessible targets. However, degrader discovery and optimization remains an inefficient process due to a lack of understanding of the relative importance of the key molecular events required to induce target degradation. Here, we use chemo-proteomics to annotate the degradable kinome. Our expansive da ...[more]