Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Colon
DISEASE(S): Colon Cancer
SUBMITTER: Gilad Vainer
LAB HEAD: Gilad W. Vainer
PROVIDER: PXD019254 | Pride | 2020-07-10
REPOSITORIES: Pride
Vainer Elez D ED Kania-Almog Juliane J Zatara Ghadeer G Levin Yishai Y Vainer Gilad W GW
Molecular & cellular proteomics : MCP 20200708 10
Using a simple, environment friendly proteome extraction (TOP), we were able to optimize the analysis of clinical samples. Using our TOP method we analyzed a clinical cohort of microsatellite stable (MSS) and unstable (MSI-H) colorectal carcinoma (CRC). We identified a tumor cell specific, STAT1-centered, immune signature expressed by the MSI-H tumor cells. We then showed that long, but not short, exposure to Interferon-γ induces a similar signature <i>in vitro</i> We identified 10 different tem ...[more]