BioID2-Synapsin proteome Soderling
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: 
Erik Soderblom
LAB HEAD: Erik Soderblom
PROVIDER: PXD019342 | Pride | 2021-07-15
REPOSITORIES: Pride
Publications
Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans.
Courtland Jamie L JL Bradshaw Tyler Wa TW Waitt Greg G Soderblom Erik J EJ Ho Tricia T Rajab Anna A Vancini Ricardo R Kim Il Hwan IH Soderling Scott H SH
eLife 20210322
Mutation of the Wiskott-Aldrich syndrome protein and SCAR homology (WASH) complex subunit, SWIP, is implicated in human intellectual disability, but the cellular etiology of this association is unknown. We identify the neuronal WASH complex proteome, revealing a network of endosomal proteins. To uncover how dysfunction of endosomal SWIP leads to disease, we generate a mouse model of the human <i>WASHC4<sup>c.3056C>G</sup></i> mutation. Quantitative spatial proteomics analysis of SWIP<sup>P1019R< ...[more]
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