The OPTN interactome using BioID
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Htert-rpe1 Cell, Cell Culture
SUBMITTER: 
Thomas O'Loughlin
LAB HEAD: Folma Buss
PROVIDER: PXD019386 | Pride | 2020-06-16
REPOSITORIES: Pride
Publications
OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion.
O'Loughlin Thomas T Kruppa Antonina J AJ Ribeiro Andre L R ALR Edgar James R JR Ghannam Abdulaziz A Smith Andrew M AM Buss Folma F
Journal of cell science 20200615 12
Optineurin (OPTN) is a multifunctional protein involved in autophagy and secretion, as well as nuclear factor κB (NF-κB) and IRF3 signalling, and <i>OPTN</i> mutations are associated with several human diseases. Here, we show that, in response to viral RNA, OPTN translocates to foci in the perinuclear region, where it negatively regulates NF-κB and IRF3 signalling pathways and downstream pro-inflammatory cytokine secretion. These OPTN foci consist of a tight cluster of small membrane vesicles, w ...[more]
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