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A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

ABSTRACT: This dataset contains RAW files from a large-scale survey of brain protein phosphorylation. It is part of a larger project that contains data from a large-scale survey of protein expression and phosphorylation encompassing nine mouse tissues: brain, brown fat, heart, kidney, liver, lung, pancreas, spleen, and testis. Protein expression was surveyed by GeLC-MS, while protein phosphorylation was assessed via a combination of SCX-IMAC enrichment

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Lung, Liver, Kidney

DISEASE(S): Disease Free

SUBMITTER: Edward Huttlin

LAB HEAD: Steven Gygi

PROVIDER: PXD019394 | Pride | 2020-05-26

REPOSITORIES: Pride

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A tissue-specific atlas of mouse protein phosphorylation and expression.

Huttlin Edward L EL Jedrychowski Mark P MP Elias Joshua E JE Goswami Tapasree T Rad Ramin R Beausoleil Sean A SA Villén Judit J Haas Wilhelm W Sowa Mathew E ME Gygi Steven P SP

Cell 20101201 7

Although most tissues in an organism are genetically identical, the biochemistry of each is optimized to fulfill its unique physiological roles, with important consequences for human health and disease. Each tissue's unique physiology requires tightly regulated gene and protein expression coordinated by specialized, phosphorylation-dependent intracellular signaling. To better understand the role of phosphorylation in maintenance of physiological differences among tissues, we performed proteomic ...[more]

PMID: 21183079

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