MS analysis of SARS-CoV2 proteins from patient samples

ABSTRACT: We developed a simple, MS-based method to specifically detect SARS-CoV-2 proteins from gargle solution samples of COVID-19 patients. Our protocol consists of an acetone precipitation and tryptic digestion of proteins contained within the gargle solution, followed by a targeted MS analysis. Our methodology identifies unique peptides originating from SARS-CoV-2 nucleoprotein. Building on these promising initial results, faster MS protocols can now be developed as routine diagnostic tools for COVID-19 patients. https://biorxiv.org/cgi/content/short/2020.04.18.047878v1

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Saliva

DISEASE(S): Severe Acute Respiratory Syndrome

SUBMITTER: Christian Ihling  

LAB HEAD: Andrea Sinz

PROVIDER: PXD019423 | Pride | 2020-06-26

REPOSITORIES: Pride