Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: Fiorella Andrea Solari
LAB HEAD: Albert Sickmann
PROVIDER: PXD019520 | Pride | 2021-05-31
REPOSITORIES: Pride
Action | DRS | |||
---|---|---|---|---|
Galactose11-24.msf | Msf | |||
Galactose2-10.msf | Msf | |||
Glucose11-24.msf | Msf | |||
Glucose2-10.msf | Msf | |||
Velos02_13611GlucF220.raw | Raw |
Items per page: 5 1 - 5 of 16 |
Walter Corvin C Marada Adinarayana A Suhm Tamara T Ernsberger Ralf R Muders Vera V Kücükköse Cansu C Sánchez-Martín Pablo P Hu Zehan Z Aich Abhishek A Loroch Stefan S Solari Fiorella Andrea FA Poveda-Huertes Daniel D Schwierzok Alexandra A Pommerening Henrike H Matic Stanka S Brix Jan J Sickmann Albert A Kraft Claudine C Dengjel Jörn J Dennerlein Sven S Brummer Tilman T Vögtle F-Nora FN Meisinger Chris C
Nature communications 20210713 1
The translocase of the outer mitochondrial membrane TOM constitutes the organellar entry gate for nearly all precursor proteins synthesized on cytosolic ribosomes. Thus, TOM presents the ideal target to adjust the mitochondrial proteome upon changing cellular demands. Here, we identify that the import receptor TOM70 is targeted by the kinase DYRK1A and that this modification plays a critical role in the activation of the carrier import pathway. Phosphorylation of TOM70<sup>Ser91</sup> by DYRK1A ...[more]