Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Embryonic Stem Cell
SUBMITTER: Markus Hartl
LAB HEAD: Martin Leeb
PROVIDER: PXD019588 | Pride | 2022-03-09
REPOSITORIES: Pride
Huth Michelle M Santini Laura L Galimberti Elena E Ramesmayer Julia J Titz-Teixeira Fabian F Sehlke Robert R Oberhuemer Michael M Stummer Sarah S Herzog Veronika V Garmhausen Marius M Romeike Merrit M Chugunova Anastasia A Leesch Friederike F Holcik Laurenz L Weipoltshammer Klara K Lackner Andreas A Schoefer Christian C von Haeseler Arndt A Buecker Christa C Pauli Andrea A Ameres Stefan L SL Smith Austin A Beyer Andreas A Leeb Martin M
Genes & development 20220303 5-6
Cell fate transitions depend on balanced rewiring of transcription and translation programs to mediate ordered developmental progression. Components of the nonsense-mediated mRNA decay (NMD) pathway have been implicated in regulating embryonic stem cell (ESC) differentiation, but the exact mechanism is unclear. Here we show that NMD controls expression levels of the translation initiation factor <i>Eif4a2</i> and its premature termination codon-encoding isoform (<i>Eif4a2</i><sup><i>PTC</i></sup ...[more]