The pan-HER kinase inhibitor Neratinib modulates plant defense signaling by covalent targeting of an Arabidopsis epoxide hydrolase

ABSTRACT: The goal of this project was to identify the target of the human covalent kinase inhibitor drug neratinib in Arabidopsis samples. To this end we applied activity-based protein profilling using the neratinib alkyne derivative.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Arabidopsis Thaliana (mouse-ear Cress)

TISSUE(S): Seedling, Cell Culture

SUBMITTER: Farnusch Kaschani  

LAB HEAD: Farnusch Kaschani

PROVIDER: PXD019640 | Pride | 2023-04-21

REPOSITORIES: Pride