Co-IP of fHERV-K env protein and interactors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Jeffrey Kowalak
LAB HEAD: Jeffrey A Kowalak
PROVIDER: PXD019702 | Pride | 2020-07-06
REPOSITORIES: Pride
Publications
Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway.
Wang Tongguang T Medynets Marie M Johnson Kory R KR Doucet-O'Hare Tara T TT DiSanza Brianna B Li Wenxue W Xu Yadi Y Bagnell Anna A Tyagi Richa R Sampson Kevon K Malik Nasir N Steiner Joseph J Hadegan Alina A Kowalak Jeffrey J O'Malley James J Maric Dragan D Nath Avindra A
Proceedings of the National Academy of Sciences of the United States of America 20200715 30
Stem cells are capable of unlimited proliferation but can be induced to form brain cells. Factors that specifically regulate human development are poorly understood. We found that human stem cells expressed high levels of the envelope protein of an endogenized human-specific retrovirus (HERV-K, HML-2) from loci in chromosomes 12 and 19. The envelope protein was expressed on the cell membrane of the stem cells and was critical in maintaining the stemness via interactions with CD98HC, leading to t ...[more]
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