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Comparative proteomic profiling of 3T3-L1 adipocyte differentiation using SILAC quantification

ABSTRACT: Comparative proteomic profiling of 3T3-L1 adipocyte differentiation using SILAC quantification

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Fibroblast

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Sunkyu Choi

LAB HEAD: Sunkyu Choi

PROVIDER: PXD019716 | Pride | 2020-10-26

REPOSITORIES: Pride

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Comparative Proteomic Profiling of 3T3-L1 Adipocyte Differentiation Using SILAC Quantification.

Choi Sunkyu S Goswami Neha N Schmidt Frank F

Journal of proteome research 20201008 12

Adipocyte differentiation is a general physiological process that is also critical for metabolic syndrome. In spite of extensive study in the past two decades, adipogenesis is a still complex cellular process that is accompanied by complicated molecular mechanisms. Here, we performed SILAC-based quantitative global proteomic profiling of 3T3-L1 adipocyte differentiation. We report protein changes to the proteome profiles, with 354 proteins exhibiting significant increase and 56 proteins showing ...[more]

PMID: 32991178

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