Proteomic analysis of SYNCRIP deficient HSPCs
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Stem Cell
DISEASE(S): Acute Leukemia
SUBMITTER: 
Alex Kentsis
LAB HEAD: Alex Kentsis
PROVIDER: PXD019779 | Pride | 2023-05-10
REPOSITORIES: Pride
Publications
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.
Herrejon Chavez Florisela F Luo Hanzhi H Cifani Paolo P Pine Alli A Chu Karen L KL Joshi Suhasini S Barin Ersilia E Schurer Alexandra A Chan Mandy M Chang Kathryn K Han Grace Y Q GYQ Pierson Aspen J AJ Xiao Michael M Yang Xuejing X Kuehm Lindsey M LM Hong Yuning Y Nguyen Diu T T DTT Chiosis Gabriela G Kentsis Alex A Leslie Christina C Vu Ly P LP Kharas Michael G MG
Nature communications 20230421 1
Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantation. Here, using a conditional knockout mouse model, we revealed that the RNA-binding protein SYNCRIP is required for maintenance of blood homeostasis especially after regenerative stress due to defects in HSCs and progenitors. Mechanistically, we find that SYN ...[more]
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