HDX-MS of VDR-RXR in complex with ZK168281
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Synapt MS
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Anna Belorusova
LAB HEAD: Tomas Leek
PROVIDER: PXD019810 | Pride | 2020-12-16
REPOSITORIES: Pride
Publications
Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia.
Rovito Daniela D Belorusova Anna Y AY Chalhoub Sandra S Rerra Anna-Isavella AI Guiot Elvire E Molin Arnaud A Linglart Agnès A Rochel Natacha N Laverny Gilles G Metzger Daniel D
Nature communications 20201207 1
The bioactive vitamin D<sub>3</sub>, 1α,25(OH)<sub>2</sub>D<sub>3</sub>, plays a central role in calcium homeostasis by controlling the activity of the vitamin D receptor (VDR) in various tissues. Hypercalcemia secondary to high circulating levels of vitamin D<sub>3</sub> leads to hypercalciuria, nephrocalcinosis and renal dysfunctions. Current therapeutic strategies aim at limiting calcium intake, absorption and resorption, or 1α,25(OH)<sub>2</sub>D<sub>3</sub> synthesis, but are poorly efficie ...[more]
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