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Differential protein expression between ESCC and normal tissues

ABSTRACT: To understand the difference of protein expression between paired esophageal squamous cell carcinoma (ESCC) and adjacent normal tissues, we collected 10 paired ESCC and normal tissues from surgical resected specimems for high-throughput proteomic experiments. From comparative analysis, the dysregulated signaling pathways in ESCC could be uncovered.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Esophageal Squamous Epithelium

DISEASE(S): Esophageal Cancer

SUBMITTER: Wei Wu

LAB HEAD: Wei Wu

PROVIDER: PXD019834 | Pride | 2020-08-11

REPOSITORIES: Pride

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Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma.

Cao Wei W Lee Hayan H Wu Wei W Zaman Aubhishek A McCorkle Sean S Yan Ming M Chen Justin J Xing Qinghe Q Sinnott-Armstrong Nasa N Xu Hongen H Sailani M Reza MR Tang Wenxue W Cui Yuanbo Y Liu Jia J Guan Hongyan H Lv Pengju P Sun Xiaoyan X Sun Lei L Han Pengli P Lou Yanan Y Chang Jing J Wang Jinwu J Gao Yuchi Y Guo Jiancheng J Schenk Gundolf G Shain Alan Hunter AH Biddle Fred G FG Collisson Eric E Snyder Michael M Bivona Trever G TG

Nature communications 20200722 1

Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to delineate the methylome landscape and characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ESCC genome. Hypo-methylated regions are enriched in areas with heterochromatin binding markers (H3K9me3, H3K27me3), while hyper-methylated regions are enriched in polycomb repressive complex (EZH2/SUZ1 ...[more]

PMID: 32699215

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