Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell
DISEASE(S): Disease Free
SUBMITTER: Wenzhang Chen
LAB HEAD: Wenzhang Chen
PROVIDER: PXD019868 | Pride | 2021-09-09
REPOSITORIES: Pride
Ma Peixiang P Ren Ping P Zhang Chuyue C Tang Jiaxing J Yu Zheng Z Zhu Xuekai X Fan Kun K Li Guanglei G Zhu Wei W Sang Wei W Min Chenyu C Chen Wenzhang W Huang Xingxu X Yang Guang G Lerner Richard A RA
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20210129 6
Using T-cell chimeric antigen receptors (CAR-T) to activate and redirect T cells to tumors expressing the cognate antigen represents a powerful approach in cancer therapy. However, normal tissues with low expression of tumor-associated antigens (TAAs) can be mistargeted, resulting in severe side effects. An approach using a collection of T cells expressing a diverse, 10<sup>6</sup>-member combinatorial cellular library of CARs, in which members can be specifically enriched based on avidity for c ...[more]