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Absolute quantification of TNF-RSC members from isolated TNF-RSC from A549 cells

ABSTRACT: Determination of absolute abundance of TNF-RSC members in the isolated TNF-RSC.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Federico Uliana

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD019879 | Pride | 2022-10-13

REPOSITORIES: Pride

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Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.

Ciuffa Rodolfo R Uliana Federico F Uliana Federico F Mannion Jonathan J Mehnert Martin M Tenev Tencho T Marulli Cathy C Satanowski Ari A Keller Lena Maria Leone LML Rodilla Ramírez Pilar Natalia PN Ori Alessandro A Gstaiger Matthias M Meier Pascal P Aebersold Ruedi R

Proceedings of the National Academy of Sciences of the United States of America 20220930 40

Protein-protein interactions (PPIs) represent the main mode of the proteome organization in the cell. In the last decade, several large-scale representations of PPI networks have captured generic aspects of the functional organization of network components but mostly lack the context of cellular states. However, the generation of context-dependent PPI networks is essential for structural and systems-level modeling of biological processes-a goal that remains an unsolved challenge. Here we describ ...[more]

PMID: 36179048

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