Dataset Information

Versican in murine cell line supernatants

ABSTRACT: The tumor derived Versican (VCAN) can be a possible mediator of the host NF-κB pathway in cancer pathogenesis. In this context, we defined VCAN function in the pathogenesis development in vitro with cell lines as well as in vivo with mouse model. We used the proteomic technique to quantify VCAN integrity and relative abundancy produced by different cancer cell lines and to link this information to our pre-existing data. These results helped us to finalise our dataset and define more clearly VCAN influence tumor development.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Lung Adenocarcinoma,Colon Cancer,Pancreas Adenocarcinoma,Disease Free,Skin Melanoma

SUBMITTER: Georgios Stathopoulos

LAB HEAD: Georgios T. STATHOPOULOS

PROVIDER: PXD019883 | Pride | 2023-05-10

REPOSITORIES: Pride

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Publications

Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ.

Spella Magda M Ntaliarda Giannoula G Skiadas Georgios G Lamort Anne-Sophie AS Vreka Malamati M Marazioti Antonia A Lilis Ioannis I Bouloukou Eleni E Giotopoulou Georgia A GA Pepe Mario A A MAA Weiss Stefanie A I SAI Petrera Agnese A Hauck Stefanie M SM Koch Ina I Lindner Michael M Hatz Rudolph A RA Behr Juergen J Arendt Kristina A M KAM Giopanou Ioanna I Brunn David D Savai Rajkumar R Jenne Dieter E DE de Château Maarten M Yull Fiona E FE Blackwell Timothy S TS Stathopoulos Georgios T GT

Cancers 20230320 6

Kirsten rat sarcoma virus (KRAS)-mutant cancers are frequent, metastatic, lethal, and largely undruggable. While interleukin (IL)-1β and nuclear factor (NF)-κB inhibition hold promise against cancer, untargeted treatments are not effective. Here, we show that human KRAS-mutant cancers are addicted to IL-1β via inflammatory versican signaling to macrophage inhibitor of NF-κB kinase (IKK) β. Human pan-cancer and experimental NF-κB reporter, transcriptome, and proteome screens reveal ...[more]

PMID: 36980752

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Dataset Information

Versican in murine cell line supernatants

Publications

Non-Oncogene Addiction of <i>KRAS</i>-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ.

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