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A research and new understanding for autoimmune sterility from seminal plasma proteomics

ABSTRACT: The global infertility rate has been increasing annually, and male infertility becoming severe. The proportion of idiopathic infertility is high, with most patients with ambiguous clinical symptoms. These symptoms manifested as declining semen quality, and the effects of autoimmune factors on this measure of fertility cannot be ignored. Aside from anti-sperm antibody for autoimmune infertility, detection indexes for male infertility are lacking. We successfully collected seminal fluid via electric stimulation from an experimental model of autoimmune orchitis in rats. We used the most advanced isobaric tags for relative and absolute quantitative proteomics analysis to analyze the seminal plasma of autoimmune infertility.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Seminal Plasma

SUBMITTER: Zun pan Fan

LAB HEAD: Zun pan Fan

PROVIDER: PXD019976 | Pride | 2025-05-06

REPOSITORIES: Pride

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	Z9064TQ_1.raw	Raw
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Publications

Seminal plasma S100A8/A9 as a potential biomarker of genital tract inflammation.

Shen Qiu-Zi QZ Wang Yong-Feng YF Fang Yi-Wei YW Chen Yuan-Yao YY He Li-Ting LT Zhang Yuan Y Liu Guo-Tao GT Zhao Kai K Liu Chun-Yan CY Fan Zun-Pan ZP Zhang Hui-Ping HP

Asian journal of andrology 20240507 5

<h4>Abstract</h4>Infections and inflammatory reactions in the male genital tract are the leading causes of male infertility with a prevalence of 6%-10%, primarily affecting testicular and epididymal function and ultimately compromising sperm quality. However, most infertile patients with genital infection/inflammation are asymptomatic and easily overlooked. Traditional indicators, including white blood cells, elastase, and other components in semen, can reflect inflammation of the genital tract, ...[more]

PMID: 38727211

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