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Equine gluteal muscle LC-MSMS: Thoroughbred

ABSTRACT: Recurrent exertional rhabdomyolysis (RER) develops in 5-10% of Thoroughbred racehorses. High-stress environments, nervous temperament, and diet influence the presentation of RER. RER-susceptibility is associated with alterations in intramuscular Ca2+ regulation with detrimental effects on mitochondria. Our study aims to determine underlying molecular drivers influencing RER-susceptibility by comparing the muscle proteome of control, RER-susceptible, and RER horses treated with dantrolene. Animals used in this study were Thoroughbred mares in race training between episodes of RER.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Equus Caballus (horse)

TISSUE(S): Gluteal Muscle, Skeletal Muscle Tissue

SUBMITTER: Stephanie Valberg

LAB HEAD: Stephanie Valberg

PROVIDER: PXD020100 | Pride | 2021-01-07

REPOSITORIES: Pride

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