Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Pharynx
DISEASE(S): Head And Neck Squamous Cell Carcinoma
SUBMITTER: Yoelsis Garcia-Mayea
LAB HEAD: Matilde Esther LLeonart Pajarin
PROVIDER: PXD020159 | Pride | 2020-11-12
REPOSITORIES: Pride
Cancers 20201105 11
Sensitization of resistant cells and cancer stem cells (CSCs) represents a major challenge in cancer therapy. A proteomic study revealed tetraspanin-1 (TSPAN1) as a protein involved in acquisition of cisplatin (CDDP) resistance (Data are available via ProteomeXchange with identifier PXD020159). TSPAN1 was found to increase in CDDP-resistant cells, CSCs and biopsies from head and neck squamous cell carcinoma (HNSCC) patients. TSPAN1 depletion in parental and CDDP-resistant HNSCC cells reduced cel ...[more]