Human Lung cancer proteomics and proteogenomics LC/MS&MS

ABSTRACT: In this project, a cohort of early stage NSCLC samples (141) were analyzed by MS-based proteomics in order to identify molecular subtypes at the phenotype level. In total, close to 14 000 proteins were identified and quantified across samples by HiRIEF-LC-MS and TMT based relative quantification. Further, six identified NSCLC proteome subtypes were investigated in relation to cancer driver pathways, immune phenotypes and neoantigen expression based on the generated MS-data.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

DISEASE(S): Lung Cancer

SUBMITTER: Georgios Mermelekas  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD020191 | Pride | 2021-12-15

REPOSITORIES: Pride