Identify proteins that interact with CDC25B
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Breast Cancer Cell Line
DISEASE(S): Breast Cancer
SUBMITTER: 
Xiaojia Tang
LAB HEAD: Liewei Wang
PROVIDER: PXD020368 | Pride | 2021-09-09
REPOSITORIES: Pride
Publications
CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer.
Cairns Junmei J Ly Reynold C RC Niu Nifang N Kalari Krishna R KR Carlson Erin E EE Wang Liewei L
NAR cancer 20201221 4
Cell division cycle 25 (CDC25) dual specificity phosphatases positively regulate the cell cycle by activating cyclin-dependent kinase/cyclin complexes. Here, we demonstrate that in addition to its role in cell cycle regulation, CDC25B functions as a regulator of protein phosphatase 2A (PP2A), a major cellular Ser/Thr phosphatase, through its direct interaction with PP2A catalytic subunit. Importantly, CDC25B alters the regulation of AMP-activated protein kinase signaling (AMPK) by PP2A, increasi ...[more]
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