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Gender differences in human endothelial cell secretome

ABSTRACT: We performed proteomic and gene ontology (GO) analyses of secretome from human serum-deprived male and female endothelial cells (ECs).

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell, Vein Endothelial Cell

SUBMITTER: Maura Brioschi

LAB HEAD: Cristina banfi

PROVIDER: PXD020375 | Pride | 2021-09-09

REPOSITORIES: Pride

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Sex-dependent differences in the secretome of human endothelial cells.

Cattaneo Maria Grazia MG Banfi Cristina C Brioschi Maura M Lattuada Donatella D Vicentini Lucia M LM

Biology of sex differences 20210107 1

<h4>Background</h4>Cellular sex has rarely been considered as a biological variable in preclinical research, even when the pathogenesis of diseases with predictable sex differences is studied. In this perspective, proteomics, and "omics" approaches in general, can provide powerful tools to obtain comprehensive cellular maps, thus favoring the discovery of still unknown sex-biased physio-pathological mechanisms.<h4>Methods</h4>We performed proteomic and Gene Ontology (GO) analyses of the secretom ...[more]

PMID: 33413676

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