Proteomics

Dataset Information

0

Genome- and proteome-wide analysis of lysine acetylation in Vibrio vulnificus Vv180806 reveals its regulatory roles in virulence and antibiotic resistance

ABSTRACT: V. vulnificus is an emergent pathogen and causes deadly septicemia in human. Protein acetylation regulates many important biological processes in bacteria. In this study, we identified the first lysine acetylome of V. vulnificus based on the whole-genome sequence of a cefoxitin-resistant strain isolated from a mortality case in China. A total of 6,626 acetylation sites at 1,924 acetylated proteins were uncovered, which to our knowledge represented the largest acetylated protein number that has been identified in bacteria. The presence of acetylation sites in virulence- and antibiotic resistance-related proteins further indicated the important role of acetylated modification on bacterial virulence and antibiotic resistance. Further investigation on the regulatory mechanisms will provide a better understanding of pathogen-host interactions in this increasingly pathogen.

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Vibrio Vulnificus Vv

SUBMITTER: Rui Pang  

LAB HEAD: Rui Pang

PROVIDER: PXD020376 | Pride | 2020-12-01

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Genome- and Proteome-Wide Analysis of Lysine Acetylation in <i>Vibrio vulnificus</i> Vv180806 Reveals Its Regulatory Roles in Virulence and Antibiotic Resistance.

Pang Rui R   Li Ying Y   Liao Kang K   Guo Penghao P   Li Yanping Y   Yang Xiaojuan X   Zhang Shuhong S   Lei Tao T   Wang Juan J   Chen Moutong M   Wu Shi S   Xue Liang L   Wu Qingping Q  

Frontiers in microbiology 20201105

Infection with <i>Vibrio vulnificus</i> is notorious for its atypical clinical manifestations and irreversible disease progression. Lysine acetylation is a conserved post-translational modification (PTM) that plays a critical regulatory role in diverse cellular processes. However, little is known about the role of lysine acetylation on the pathogenesis of <i>V. vulnificus</i>. Here, we report the complete genome sequence and a global profile for protein lysine acetylation of <i>V. vulnificus</i>  ...[more]

Similar Datasets

Proteomics Acetylome of Acinetobacter baumannii SK17 reveals a highly-conserved modification of histone-like protein HU
2018-10-24 | PXD007289 | Pride
Proteomics The acetylome analysis of lysine acetylation in the plant pathogenic bacterium Brenneria nigrifluens
2019-09-30 | PXD014046 | Pride
Proteomics Quantitative acetylome analysis of Fusarium oxysporum
2022-06-09 | PXD029583 | Pride
Proteomics Quantitative proteomic analysis of global protein acetylation in PRRSV infected pulmonary alveolar macrophages
2020-12-11 | PXD016927 | Pride
Proteomics Functional insights into protein acetylation in the hyperthermophilic archaeon Sulfolobus islandicus
2019-06-12 | PXD012246 | Pride
Proteomics The global acetylome of the human pathogen Vibrio cholerae V52 reveals lysine acetylation of major transcriptional regulators
2018-01-02 | PXD008055 | Pride
Proteomics mice Renal tubular epithelial cells LC-MS/MS
2022-02-17 | PXD029651 | Pride
Proteomics Quantitative analysis of acetylation in Vero cells infected with Peste des petits ruminants virus
2023-10-24 | PXD025081 | Pride
Proteomics Phytoplasma induced changes in acetylatome and succinylatome provide evidence for involvement of acetylated proteins in Paulownia witches’ broom
2019-04-04 | PXD012701 | Pride
Proteomics Systematic analysis of the lysine acetylome in Beauveria bassiana
2017-11-02 | PXD003682 | Pride