Phenotypical adaptation of Pseudomonas aeruginosa in the presence of siderophore-antibiotic conjugates during epithelial cell infection

ABSTRACT: This study aims at investigating the ability of Pseudomonas aeruginosa to detect the presence of siderophore-antibiotic conjugates in an epithelial cell infection assay. We show that the presence of siderophore-antibiotic conjugates induces the transcription and expression of their corresponding transporters, indicating the bacteria are able to sense the chelators in their environment and adapt their phenotype accordingly.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human) Pseudomonas Aeruginosa Pao1

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Paola Cantero  

LAB HEAD: Laurence Sabatier

PROVIDER: PXD020378 | Pride | 2021-02-18

REPOSITORIES: Pride