PROTOMAP analysis of Human Cartoid Plaques
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, LTQ
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Heart
SUBMITTER: 
Melissa Dix
LAB HEAD: Benjamin Cravatt
PROVIDER: PXD020405 | Pride | 2020-08-10
REPOSITORIES: Pride
Publications
Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture.
Vaisar Tomáš T Hu Jie H JH Airhart Nathan N Fox Kate K Heinecke Jay J Nicosia Roberto F RF Kohler Ted T Potter Zachary E ZE Simon Gabriel M GM Dix Melissa M MM Cravatt Benjamin F BF Gharib Sina A SA Dichek David A DA
Circulation research 20200730 8
<h4>Rationale</h4>Plaque rupture is the proximate cause of most myocardial infarctions and many strokes. However, the molecular mechanisms that precipitate plaque rupture are unknown.<h4>Objective</h4>By applying proteomic and bioinformatic approaches in mouse models of protease-induced plaque rupture and in ruptured human plaques, we aimed to illuminate biochemical pathways through which proteolysis causes plaque rupture and identify substrates that are cleaved in ruptured plaques.<h4>Methods a ...[more]
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