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Wild-type and O/E uPA in mouse aortic arches_PROTOMAP

ABSTRACT: Aortic arches from WT and overexpression of uPA were extracted and their proteome was processed and subjected to PROTOMAP analysis.

INSTRUMENT(S): LTQ

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Melissa Dix

LAB HEAD: Benjamin Cravatt

PROVIDER: PXD020406 | Pride | 2020-08-10

REPOSITORIES: Pride

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Publications

Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture.

Vaisar Tomáš T Hu Jie H JH Airhart Nathan N Fox Kate K Heinecke Jay J Nicosia Roberto F RF Kohler Ted T Potter Zachary E ZE Simon Gabriel M GM Dix Melissa M MM Cravatt Benjamin F BF Gharib Sina A SA Dichek David A DA

Circulation research 20200730 8

<h4>Rationale</h4>Plaque rupture is the proximate cause of most myocardial infarctions and many strokes. However, the molecular mechanisms that precipitate plaque rupture are unknown.<h4>Objective</h4>By applying proteomic and bioinformatic approaches in mouse models of protease-induced plaque rupture and in ruptured human plaques, we aimed to illuminate biochemical pathways through which proteolysis causes plaque rupture and identify substrates that are cleaved in ruptured plaques.<h4>Methods a ...[more]

PMID: 32762496

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