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Prednisolone alters decidualization and affects decidual-trophoblast interactions

ABSTRACT: Identification of cellular proteins in human endometrial stromal fibroblasts decidualized for 13 days in vitro. Fibroblasts were cultured under normal culture conditions (5% CO2 in 2% charcoal stripped FBS) and treated with prednisolone (0.5ug/ml) or vehicle control (DMSO) every 48-72h for 13 days

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Endometrial Stromal Cell, Endometrial Stroma, Fibroblast

SUBMITTER: Swati Varshney

LAB HEAD: Ellen Menkhorst

PROVIDER: PXD020543 | Pride | 2021-04-27

REPOSITORIES: Pride

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Prednisolone Alters Endometrial Decidual Cells and Affects Decidual-Trophoblast Interactions.

Grbac Eliza E So Teresa T Varshney Swati S Williamson Nicholas N Dimitriadis Evdokia E Menkhorst Ellen E

Frontiers in cell and developmental biology 20210409

Poor pregnancy outcomes such as recurrent pregnancy loss (RPL) and preeclampsia are associated with impaired decidualization and abnormal trophoblast invasion. Emerging evidence suggests that use of corticosteroids, including prednisolone affects fertility by altering uterine function and may be associated with preeclampsia incidence. In this study, using primary and gestational-age appropriate tissue, we aimed to define the effect of prednisolone on human endometrial stromal fibroblast (hESF) d ...[more]

PMID: 33898438

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