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Human breast cancer cell line LC-MS/MS

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive type with poor prognosis among the breast cancers and has a high population of cancer stem cells (CSCs) which are main target to cure and inhibit TNBC. In this study, we analyzed the CSC-related proteome alteration by NEDD4 knockdown in CSC-abundant MDA-MB-231 cells by LC-MS/MS analysis.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Seon-Ae Jeon

LAB HEAD: Je-Yoel Cho

PROVIDER: PXD020585 | Pride | 2021-09-09

REPOSITORIES: Pride

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NEDD4 Plays Roles in the Maintenance of Breast Cancer Stem Cell Characteristics.

Jeon Seon-Ae SA Kim Dong Wook DW Lee Da-Bin DB Cho Je-Yoel JY

Frontiers in oncology 20200902

Triple-negative breast cancer (TNBC) is the most aggressive type with poor prognosis among the breast cancers and has a high population of cancer stem cells (CSCs), which are the main target to cure and inhibit TNBC. In this study, we examined the role of neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) in the proliferation, migration, and CSC characteristics of MDA-MB-231, a TNBC cell line. Interestingly, the Kaplan-Meier plotter showed that the survival rate of p ...[more]

PMID: 33014839

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