Dataset Information
ATR interactome in Homo sapiens bone osteosarcoma U2OS cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
vittoria matafora
LAB HEAD: Angela Bachi
PROVIDER: PXD020622 | Pride | 2020-09-30
REPOSITORIES: Pride
Publications
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration.
Nature communications 20200924 1
ATR responds to mechanical stress at the nuclear envelope and mediates envelope-associated repair of aberrant topological DNA states. By combining microscopy, electron microscopic analysis, biophysical and in vivo models, we report that ATR-defective cells exhibit altered nuclear plasticity and YAP delocalization. When subjected to mechanical stress or undergoing interstitial migration, ATR-defective nuclei collapse accumulating nuclear envelope ruptures and perinuclear cGAS, which indicate loss ...[more]
