Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Escherichia Coli
TISSUE(S): Cell Suspension Culture
SUBMITTER: Witold Szymanski
LAB HEAD: Victor Sourjik
PROVIDER: PXD020710 | Pride | 2020-08-14
REPOSITORIES: Pride
Teteneva Nataliya A NA Mart'yanov Sergey V SV Esteban-López María M Kahnt Jörg J Glatter Timo T Netrusov Alexander I AI Plakunov Vladimir K VK Sourjik Victor V
Applied and environmental microbiology 20201015 21
In most ecosystems, bacteria exist primarily as structured surface-associated biofilms that can be highly tolerant to antibiotics and thus represent an important health issue. Here, we explored drug repurposing as a strategy to identify new antibiofilm compounds, screening over 1,000 compounds from the Prestwick Chemical Library of approved drugs for specific activities that prevent biofilm formation by <i>Escherichia coli</i> Most growth-inhibiting compounds, which include known antibacterial b ...[more]