Proteomics analysis of 80S ribosomes in nine mouse tissues and different developmental stages of testes
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, Heart, Testis, Brain, Lung, Liver, Kidney
SUBMITTER: 
Xuejiang Guo
LAB HEAD: Xuejiang Guo
PROVIDER: PXD020864 | Pride | 2022-10-05
REPOSITORIES: Pride
Publications
A male germ-cell-specific ribosome controls male fertility.
Li Huiling H Huo Yangao Y He Xi X Yao Liping L Zhang Hao H Cui Yiqiang Y Xiao Huijuan H Xie Wenxiu W Zhang Dejiu D Wang Yue Y Zhang Shu S Tu Haixia H Cheng Yiwei Y Guo Yueshuai Y Cao Xintao X Zhu Yunfei Y Jiang Tao T Guo Xuejiang X Qin Yan Y Sha Jiahao J
Nature 20221214 7941
Ribosomes are highly sophisticated translation machines that have been demonstrated to be heterogeneous in the regulation of protein synthesis<sup>1,2</sup>. Male germ cell development involves complex translational regulation during sperm formation<sup>3</sup>. However, it remains unclear whether translation during sperm formation is performed by a specific ribosome. Here we report a ribosome with a specialized nascent polypeptide exit tunnel, Ribosome<sup>ST</sup>, that is assembled with the m ...[more]
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