Ontology highlight
ABSTRACT:
INSTRUMENT(S): QTRAP 5500
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Leukocyte, Cell Culture
SUBMITTER: Sapir Schlam
LAB HEAD: Yosef Shiloh
PROVIDER: PXD020884 | Pride | 2020-11-25
REPOSITORIES: Pride
Schlam-Babayov Sapir S Bensimon Ariel A Harel Michal M Geiger Tamar T Aebersold Ruedi R Ziv Yael Y Shiloh Yosef Y
The EMBO journal 20201120 2
The DNA damage response (DDR) is a complex signaling network that relies on cascades of protein phosphorylation, which are initiated by three protein kinases of the family of PI3-kinase-related protein kinases (PIKKs): ATM, ATR, and DNA-PK. ATM is missing or inactivated in the genome instability syndrome, ataxia-telangiectasia (A-T). The relative shares of these PIKKs in the response to genotoxic stress and the functional relationships among them are central questions in the genome stability fie ...[more]