Proteomics of induced senescent cells

ABSTRACT: OMI (Uniprot ID O43464) is a pro-apoptotic protease localized to the mitochondria which was hypothesized to activate senescense following X-ray irradiation via cleavage of specific ligands. To elucidate cellular processes affected by OMI after irradiation, human lung cancer cell line was subjected to the following treatments: WT + X-ray irradiation WT - X-ray irradiation WT + OMI-inhibitor + X-ray irradiation WT + OMI-inhibitor - X-ray irradiation OMI-siRNA + X-ray irradiation OMI-siRNA - X-ray irradiation siRNA-empty vector (control) + X-ray irradiation siRNA-empty vector (control) - X-ray irradiation

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Alon Savidor  

LAB HEAD: Prof. Adi Kimchi

PROVIDER: PXD020972 | Pride | 2022-01-30

REPOSITORIES: Pride