Identification of signalling pathways downstream of ARHGEF17
Ontology highlight
ABSTRACT: Somatic DNA copy number variations (CNVs) are prevalent in cancer and can drive cancer progression albeit with often uncharacterized roles in altering cell signaling states. We developed a computational approach to predict regulators of signaling from the integrative analysis of genomic and proteomic pan-cancer datasets. Among the predictions, we identified ARHGEF17 to be a regulator of hippo-signaling and performed (phospho)proteomics analysis to test these predictions.
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Breast Epithelium, Cell Culture
DISEASE(S): Breast Cancer
SUBMITTER: Danish Memon
LAB HEAD: Pedro Beltrao
PROVIDER: PXD021031 | Pride | 2021-04-06
REPOSITORIES: Pride
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