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Proteomics profiling of pediatric choroid plexus tumors

ABSTRACT: Aggresome is a para nuclear inclusion body that functions as a storage compartment for misfolded proteins. Our previous work revealed the presence of aggresomes in pediatric choroid plexus tumors (CPT). CPTs are rare neoplasms comprised of three pathological subgroups; choroid plexus carcinoma (CPC), a grade III tumor, atypical choroid plexus papilloma (ACPP), a grade II tumor, and choroid plexus papilloma (CPP), a grade I tumor. In the current study, we aimed to investigate the prognostic value of aggresomes-positivity and its correlation to the pathological and molecular subtypes. The proteomics profiling of 21 CPT pediatric samples was investigated using ABSciex Triple TOF 5600+ mass spectrometer.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Choroid Plexus Cancer Cell, Choroid Plexus Papilloma Cell, Choroid Plexus Epithelium

DISEASE(S): Choroid Plexus Carcinoma,Choroid Plexus Papilloma,Atypical Choroid Plexus Papilloma

SUBMITTER: Nouran Al-Shehaby

LAB HEAD: Shahenda Mahmoud El-Naggar

PROVIDER: PXD021076 | Pride | 2021-02-11

REPOSITORIES: Pride

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