Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Caenorhabditis Elegans
SUBMITTER: Carolyn Phillips
LAB HEAD: Carolyn M. Phillips
PROVIDER: PXD021227 | Pride | 2021-06-17
REPOSITORIES: Pride
Nguyen Dieu An H DAH Phillips Carolyn M CM
Nature communications 20210709 1
CSR-1 is an essential Argonaute protein that binds to a subclass of 22G-RNAs targeting most germline-expressed genes. Here we show that the two isoforms of CSR-1 have distinct expression patterns; CSR-1B is ubiquitously expressed throughout the germline and during all stages of development while CSR-1A expression is restricted to germ cells undergoing spermatogenesis. Furthermore, CSR-1A associates preferentially with 22G-RNAs mapping to spermatogenesis-specific genes whereas CSR-1B-bound small ...[more]