Proteomics

Dataset Information

Complexome profiling of mitochondrial protein complexes to study the molecular consequences of DNAJC30 mutations

ABSTRACT: We identified the chaperone DNAJC30 as an important factor to maintain NADH:ubiquinone oxidoreductase (complex I) activity. In this complexome analysis we detected DNAJC30 in substoichiometric amounts attached to respiratory supercomplexes (I/III2/IVn and demonstrate an accumulation of complex I containing respiratory supercomplexes in the patient cell line with DNAJC30 mutations compared to the control cell line.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Fibroblast

SUBMITTER: Ilka Wittig  

LAB HEAD: Holger Prokisch

PROVIDER: PXD021385 | Pride | 2021-09-09

REPOSITORIES: Pride

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Data_analysis.xlsx Xlsx
P18_048_S_LHON_Sample_108718_01.raw Raw
P18_048_S_LHON_Sample_108718_02.raw Raw
P18_048_S_LHON_Sample_108718_03.raw Raw
P18_048_S_LHON_Sample_108718_04.raw Raw
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