Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF-X, Q Exactive HF
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: David Romero-Suarez
LAB HEAD: Michael Krogh Jensen
PROVIDER: PXD021470 | Pride | 2021-02-22
REPOSITORIES: Pride
Romero-Suarez David D Wulff Tune T Rong Yixin Y Jakočiu Nas Tadas T Yuzawa Satoshi S Keasling Jay D JD Jensen Michael K MK
ACS synthetic biology 20210212 3
Protein misfolding and aggregation are linked to neurodegenerative diseases of mammals and suboptimal protein expression within biotechnology. Tools for monitoring protein aggregates are therefore useful for studying disease-related aggregation and for improving soluble protein expression in heterologous hosts for biotechnology purposes. In this work, we developed a promoter-reporter system for aggregated protein on the basis of the yeast native response to misfolded protein. To this end, we fir ...[more]