Activity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome

ABSTRACT: We measure changes in the proteome after 48 hours of activity deprivation with tetrodotoxin (TTX) and the NMDA receptor antagonist (2R)-amino-5-phosphonovaleric acid (APV). We used wild type and FMRP mutant primary cortical neurons treated with vehicle or treated with TTX-APV.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Victor Faundez  

LAB HEAD: Victor Faundez

PROVIDER: PXD021473 | Pride | 2021-09-09

REPOSITORIES: Pride