Characterisation of the adhesome of patient-derived cutaneous squamous carcinoma cells

ABSTRACT: Interactions between cells and the extracellular matrix, mediated by integrin adhesion complexes (IACs), play key roles in cancer progression and metastasis. We report here systems-level changes in the adhesome during progression of a patient-derived cutaneous squamous cell carcinoma (cSCC). We found that the actin regulatory protein Mena is enriched in IACs in metastatic cSCC cells and is connected within a subnetwork of actin-binding proteins to the LINC complex component nesprin-2.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skin

DISEASE(S): Skin Squamous Cell Carcinoma

SUBMITTER: Adam Byron  

LAB HEAD: Margaret Frame

PROVIDER: PXD021492 | Pride | 2023-03-25

REPOSITORIES: Pride