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Adult mouse cardiomyocytes in early stage of pressure overload

ABSTRACT: Adult cardiomyocytes from mouse hearts under 3 days of pressure-overload induced by transverse aortic constriction

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart, Cardiac Muscle Cell

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Yu-Wang Chang

LAB HEAD: Chien-Chang Chen

PROVIDER: PXD021671 | Pride | 2025-05-06

REPOSITORIES: Pride

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			Action	DRS
	181218-TMT-A-1ul.raw	Raw
	181218-TMT-A-1ul_20190227103813.raw	Raw
	181218-TMT-A-1ul_20190227174353.raw	Raw
	181218-TMT-B-1ul.raw	Raw
	181218-TMT-B-1ul_20190228042747.raw	Raw

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Publications

Multiomic analyses reveal enriched glycolytic processes in β-myosin heavy chain-expressed cardiomyocytes in early cardiac hypertrophy.

Yeh Hsiao-Hui HH Chang Yao-Ming YM Chang Yu-Wang YW Lu Mei-Yeh Jade MJ Chen Yi-Hua YH Lee Chia-Che CC Chen Chien-Chang CC

Journal of molecular and cellular cardiology plus 20220627

<h4>Background</h4>Cardiac pressure overload induces cardiac hypertrophy and eventually leads to heart failure. One distinct feature of pathological cardiac hypertrophy is fetal-gene re-expression, but not every cardiomyocyte exhibits fetal gene re-expression in the diseased heart. Adult cardiomyocytes are terminally differentiated cells, so we do not know how the heterogeneity is determined and whether the differential fetal-gene reprogramming indicates a different degree of remodeling among ca ...[more]

PMID: 39801720

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