Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Lung, Epithelial Cell
DISEASE(S): Idiopathic Pulmonary Fibrosis,Pulmonary Fibrosis
SUBMITTER: Ying Wai Lam
LAB HEAD: Vikas Anathy
PROVIDER: PXD021715 | Pride | 2021-11-11
REPOSITORIES: Pride
Kumar Amit A Elko Evan E Bruno Sierra R SR Mark Zoe F ZF Chamberlain Nicolas N Mihavics Bethany Korwin BK Chandrasekaran Ravishankar R Walzer Joseph J Ruban Mona M Gold Clarissa C Lam Ying Wai YW Ghandikota Sudhir S Jegga Anil G AG Gomez Jose L JL Janssen-Heininger Yvonne Mw YM Anathy Vikas V
Thorax 20210816 7
<h4>Background</h4>The role of club cells in the pathology of idiopathic pulmonary fibrosis (IPF) is not well understood. Protein disulfide isomerase A3 (PDIA3), an endoplasmic reticulum-based redox chaperone required for the functions of various fibrosis-related proteins; however, the mechanisms of action of PDIA3 in pulmonary fibrosis are not fully elucidated.<h4>Objectives</h4>To examine the role of club cells and PDIA3 in the pathology of pulmonary fibrosis and the therapeutic potential of i ...[more]