Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma, Extracellular Vesicle
DISEASE(S): Alzheimer's Disease
SUBMITTER: Rafael Posada-Duque
LAB HEAD: Rafael Andres Posada-Duque
PROVIDER: PXD021718 | Pride | 2021-09-09
REPOSITORIES: Pride
Villar-Vesga Juan J Henao-Restrepo Julián J Voshart Daniëlle C DC Aguillon David D Villegas Andrés A Castaño Diana D Arias-Londoño Julián D JD Zuhorn Inge S IS Ribovski Laís L Barazzuol Lara L Cardona-Gómez Gloria P GP Posada-Duque Rafael R
Frontiers in aging neuroscience 20201111
Evidence suggests that extracellular vesicles (EVs) act as mediators and biomarkers of neurodegenerative diseases. Two distinct forms of Alzheimer disease (AD) are known: a late-onset sporadic form (SAD) and an early-onset familial form (FAD). Recently, neurovascular dysfunction and altered systemic immunological components have been linked to AD neurodegeneration. Therefore, we characterized systemic-EVs from postmortem SAD and FAD patients and evaluated their effects on neuroglial and endothel ...[more]