Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Paul Thomas
LAB HEAD: Leonidas C. Platanias
PROVIDER: PXD021749 | Pride | 2021-04-14
REPOSITORIES: Pride
Fischietti Mariafausta M Eckerdt Frank F Blyth Gavin T GT Arslan Ahmet D AD Mati William M WM Oku Chidera V CV Perez Ricardo E RE Lee-Chang Catalina C Kosciuczuk Ewa M EM Saleiro Diana D Beauchamp Elspeth M EM Lesniak Maciej S MS Verzella Daniela D Sun Leyu L Fish Eleanor N EN Yang Guang-Yu GY Qiang Wenan W Platanias Leonidas C LC
Oncogene 20210412 18
We provide evidence that a member of the human Schlafen (SLFN) family of proteins, SLFN5, is overexpressed in human pancreatic ductal adenocarcinoma (PDAC). Targeted deletion of SLFN5 results in decreased PDAC cell proliferation and suppresses PDAC tumorigenesis in in vivo PDAC models. Importantly, high expression levels of SLFN5 correlate with worse outcomes in PDAC patients, implicating SLFN5 in the pathophysiology of PDAC that leads to poor outcomes. Our studies establish novel regulatory eff ...[more]