Dataset Information

Vaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy

ABSTRACT: This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWATH-MS strategy were applied to profile changes in protein expression at early and middle stage of pregnancy. Using in-house generated HVF-specific protein library, 61 proteins (>1.5 fold at V2/V1 or V3/V1, q-value <0.05) changed as a function of gestational age. The stage-specific expression pattern of these proteins was mainly associated with the biology of cervical remolding, fetal development and microbial defense.

INSTRUMENT(S): Q TRAP

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Vaginal Fluid

SUBMITTER: Bhoj Kumar

LAB HEAD: Tushar Kanti Maiti

PROVIDER: PXD021811 | Pride | 2021-01-28

REPOSITORIES: Pride

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Publications

Dynamic Alteration in the Vaginal Secretory Proteome across the Early and Mid-Trimesters of Pregnancy.

Kumar Bhoj B Dey Amit Kumar AK Saha Sandhini S Singh Abhishek Kumar AK Kshetrapal Pallavi P Wadhwa Nitya N Thiruvengadam Ramachandran R Desiraju Bapu Koundinya BK Bhatnagar Shinjini S Salunke Dinakar M DM Rashid Faraz F Malakar Dipankar D Maiti Tushar Kanti TK

Journal of proteome research 20210126 2

Pregnancy is characterized by intense physiological and structural alterations in the vagina, cervix, and overlying fetal membranes. High vaginal fluid (HVF) is a proximal fluid that covers the lower part of the female reproductive system and the severity of vaginal pathology often adversely affects pregnancy outcomes. To identify the correlation of vaginal fluid proteome dynamics and physiological changes during the progression of pregnancy, a longitudinal study was performed on 20 pregnant wom ...[more]

PMID: 33497241

Dataset Information

Vaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy

Publications

Dynamic Alteration in the Vaginal Secretory Proteome across the Early and Mid-Trimesters of Pregnancy.

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