Proteomics

Dataset Information

0

Arg-GlcNAcylation of Salmonella proteins

ABSTRACT: This project explores the impact of SseK mediated Arg-GlcNAcylation on Salmonella proteins. Using Site directed mutagenesis, MS analysis and phenotypic studies we show Arg-GlcNAcylation appears to modulate the functions of multiple salmonella enzymes. This work demonstrates effectors can have multiple roles both within host cells and bacterial pathogens themselves.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Salmonella Enterica Subsp. Enterica Serovar Typhimurium Str. St1489

SUBMITTER: Nichollas Scott  

LAB HEAD: Philip Hardwidge

PROVIDER: PXD021878 | Pride | 2021-09-09

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Arginine glycosylation enhances methylglyoxal detoxification.

El Qaidi Samir S   Scott Nichollas E NE   Hardwidge Philip R PR  

Scientific reports 20210215 1

Type III secretion system effector proteins have primarily been characterized for their interactions with host cell proteins and their ability to disrupt host signaling pathways. We are testing the hypothesis that some effectors are active within the bacterium, where they modulate bacterial signal transduction and physiology. We previously determined that the Citrobacter rodentium effector NleB possesses an intra-bacterial glycosyltransferase activity that increases glutathione synthetase activi  ...[more]

Similar Datasets

Proteomics Arg-GlcNAc analysis of the proteins GlmR and NagC
2022-03-10 | PXD030710 | Pride
Proteomics OmpR Arg-GlcNAcylation within Salmonella
2023-05-20 | PXD039412 | Pride
Proteomics Reversible Lysine Derivatization Enables High Specificity of Arg-C Digestion Using Trypsin
2018-01-04 | PXD007994 | Pride
Proteomics Arg-Glycosylation of NleB2 during infections
2021-05-25 | PXD025057 | Pride
Proteomics Confirmation of Arg-Glucosylation on multiple Death domain proteins
2021-05-25 | PXD025531 | Pride
Genomics Xanthomonas prunicola strain:Arg-1 | isolate:Arg-1
| PRJNA819403 | ENA
Transcriptomics Arg C and Linezolid on Th17 cells
2020-10-15 | GSE159401 | GEO
Transcriptomics Impact of tRNA-Glu(UUC) and tRNA-Arg(CCG) on mRNA abundance
2016-06-07 | GSE77285 | GEO
Genomics Helicobacter pylori ARG-G63
| PRJNA169924 | ENA
Transcriptomics Impact of tRNA-Glu(UUC) and tRNA-Arg(CCG) on mRNA stability
2016-06-07 | GSE77349 | GEO