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Fungus-host protein-protein interactions between Drechmeria coniospora and Caenorhabditis elegans

ABSTRACT: Label-free quantitative affinity purification experiments were performed to identify the host protein binders of D. coniospora fungal virulence factors in C. elegans.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Caenorhabditis Elegans

TISSUE(S): Whole Body

SUBMITTER: Jia-Xuan Chen

LAB HEAD: Jonathan J. Ewbank

PROVIDER: PXD021929 | Pride | 2020-11-20

REPOSITORIES: Pride

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Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences.

Zhang Xing X Harding Benjamin W BW Aggad Dina D Courtine Damien D Chen Jia-Xuan JX Pujol Nathalie N Ewbank Jonathan J JJ

PLoS genetics 20210624 6

Animals and plants need to defend themselves from pathogen attack. Their defences drive innovation in virulence mechanisms, leading to never-ending cycles of co-evolution in both hosts and pathogens. A full understanding of host immunity therefore requires examination of pathogen virulence strategies. Here, we take advantage of the well-studied innate immune system of Caenorhabditis elegans to dissect the action of two virulence factors from its natural fungal pathogen Drechmeria coniospora. We ...[more]

PMID: 34166401

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