Proteomics

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Global proteomics of Ubqln2-based murine models of ALS


ABSTRACT: Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that acts on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like (UBL) domain and is thought to deliver ubiquitinated proteins to proteasomes for degradation. UBQLN2 mutations result in familial ALS/FTD in humans through an unknown mechanism. Quantitative multiplexed proteomics was used to provide for the first time an unbiased and global analysis of the role of Ubqln2 in controlling the composition of the proteome. We studied several murine models of Ubqln2-linked ALS and also generated Ubqln2 null mutant mice. We identified impacts of Ubqln2 on diverse physiological pathways, most notably serotonergic signaling. Interestingly, we observed upregulation of proteasome subunits, suggesting a compensatory response to diminished proteasome output. Among the specific proteins whose abundance is linked to UBQLN2 function, the strongest hits were the ubiquitin ligase TRIM32 and two retroelement-derived proteins, PEG10 and CXX1B. Cycloheximide chase studies using induced human neurons and HEK293 cells suggested that PEG10 and TRIM32 are direct clients. Although directing the degradation of multiple proteins via the proteasome, UBQLN2 surprisingly conferred strong protection from degradation on the Gag-like protein CXX1B, which is expressed from the same family of retroelement genes as PEG10. In summary, this study charts the proteomic landscape of ALS-related Ubqln2 mutants and identifies candidate client proteins that are altered in vivo in disease models and whose degradation is promoted by UBQLN2.

INSTRUMENT(S): Orbitrap Fusion Lumos, Orbitrap Fusion

ORGANISM(S): Streptomyces lincolnensis   Acanthamoeba polyphaga mimivirus   Rhodopseudomonas palustris   Dioscorea oppositifolia   Colinus virginianus   Microbacterium sp.   Trichoderma reesei RUT C-30   Bothrops leucurus   Candida dubliniensis   Polaribacter marinivivus   Olavius algarvensis Delta 4 endosymbiont   Heloderma suspectum suspectum   Streptococcus pyogenes MGAS5005   Anopheles stephensi   Hepatitis E virus type 1   Klebsiella oxytoca   Cucumis sativus   Plasmodium falciparum 3D7   Acinetobacter calcoaceticus/baumannii complex   mixed sample   Spongiibacter nanhainus   Sulfurihydrogenibium   Parhyale hawaiensis   Galleria mellonella   Orycteropus afer   Clostridium tetani E88   Camellia sinensis   Paenibacillus sp.   unclassified Candidatus Omnitrophica   Cryptosporidium parvum   Ophrys sphegodes   Burkholderia cenocepacia H111   Moorella thermoacetica ATCC 39073   Diploria labyrinthiformis   Glia   Drosophila   Listeria monocytogenes serotype 4b   Millerozyma acaciae   Helicoverpa armigera armigera   Corucia zebrata   Saccharum officinarum   Synechococcus sp. YX04-3   Bothrops neuwiedi   Mycoplasma hyopneumoniae 232   Nicotiana forgetiana   Anacardium occidentale   Escherichia coli BL21(DE3)   Oryctolagus cuniculus   Acanthoscurria gomesiana   Nicotiana paniculata   Strawberry leafy fruit phytoplasma   Human betaherpesvirus 5   Giardia sp.   Deinococcus radiodurans ATCC 13939   Bos grunniens   Haptophyta   Rosaceae   Spironucleus salmonicida   Willaertia magna   Cyprinus carpio   Mycobacterium marinum ATCC BAA-535   Microcystis aeruginosa NIES-843   Metarhizium robertsii   Microplitis mediator   Populus cathayana   Sinorhizobium meliloti BL225C   Lasius niger   Leishmania guyanensis species complex   Brenneria nigrifluens   Hydra vulgaris   Solanum lycopersicum x Solanum tuberosum   Venturia pyrina   soil metagenome   Cervus nippon nippon   Stagonospora   Meles meles   Thermus thermophilus HB27   Planococcus halocryophilus Or1   Naja annulifera   Cryptococcus neoformans var. grubii H99W   Osphranter rufus   Nepenthes rafflesiana   Beta vulgaris subsp. vulgaris   Artemisia annua   Geobacillus thermoleovorans   Aeropyrum pernix   Pisum sativum   Radix auricularia   Mycobacterium tuberculosis   Fagus grandifolia   Crocuta crocuta   Pectobacterium carotovorum   Trichinella pseudospiralis   Austrolebias   Candidatus Brocadia sapporoensis   Rattus rattus   Marthasterias glacialis   Prunus dulcis   Anopheles culicifacies A   Trichoderma reesei QM6a   Olavius algarvensis Gamma 3 endosymbiont   Nymphicus hollandicus   Nicotiana plumbaginifolia   Eulimnogammarus cyaneus   Oryza sativa Japonica Group   Syntrophus aciditrophicus SB   Mycobacterium tuberculosis H37Ra   Solenopsis invicta   Rangifer tarandus   Campylobacter jejuni subsp. jejuni 81116   Sus scrofa domesticus   Acinetobacter baumannii ACICU   Eriocheir sinensis   Polytomella parva   Mesembryanthemum crystallinum   Morganella   Geobacter sulfurreducens   Lynx lynx   Francisella tularensis   Pseudomonas sp. 'Pseudom. M1'   Ostreococcus tauri   Frankliniella sp. BIOUG14947-G11   Spongospora sp.   Spiroplasma melliferum KC3   Mycobacterium tuberculosis CAS   Photinus pyralis   Plutella xylostella   Halobacterium   Oryza longistaminata   Quercus suber   Nitrosopumilus maritimus SCM1   Tuber albidum   Bothrops alcatraz   Flavobacterium sp. 316   Pseudomonas jessenii   Sulfobacillus thermosulfidooxidans   Porphyromonas gingivalis W83   Axis axis   Valsa mali   Paracatenula sp. 'standrea' Elba   Pseudodiploria strigosa   Aspergillus aculeatus ATCC 16872   Malassezia globosa   Clostridioides difficile R20291   Spondylus gaederopus   Pinus taeda   Mizuhopecten yessoensis   Streptomyces coelicolor   Lentibacter algarum   anaerobic digester metagenome   Helicobacter pylori 26695   Phoneutria nigriventer   Aspergillus giganteus   Capra hircus x Ovis aries   Strix varia   Elizabethkingia anophelis   Norovirus Hu/GII/JP/2015/GII.P17_GII.17/Kawasaki308   Pseudomonas aeruginosa str. 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C58   Tetratrichomonas gallinarum   Schizosaccharomyces pombe 927   Picea asperata   phytoplankton environmental sample   Corynebacterium glutamicum   Sulfolobus islandicus REY15A   Angiostrongylus cantonensis   Physcomitrium sp. Goffinet 11574   Populus deltoides   Rickettsia massiliae MTU5   Penicillium verrucosum   Cervus elaphus elaphus   Modestobacter marinus BC501   Chara australis   Cervus elaphus   Mouse mammary tumor virus   Venturia inaequalis   Zalophus californianus   Heterocephalus glaber   Lactiplantibacillus plantarum   Amblyomma cajennense   Kryptolebias marmoratus   Diplonema papillatum   Foeniculum vulgare   Ceratopteris richardii   Streptococcus equi subsp. equi 4047   Mytilus edulis   Escherichia phage T7   Streptococcus suis SC84   Odontotaenius disjunctus   Ogataea polymorpha   Cassiopea xamachana   HIV-1 M:B_HXB2R   Nepenthes ventricosa x Nepenthes alata   Rhipicephalus microplus   Mentha spicata   Mayaro virus (strain Brazil)   Brucella abortus   Triaenophorus crassus   Lactiplantibacillus plantarum subsp. plantarum   Petunia   Epichloe festucae E2368   Polyporus umbellatus GSX09   Komagataella pastoris   Pteropus alecto   Toxoplasma   Bacteria incertae sedis   Bos indicus   Pseudomonas putida   Chromera velia   Megaloceros giganteus   Mucidula mucida   Pseudomonas sp. 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Houston-1   Gardnerella vaginalis   Ecrobia   Vigna mungo   Vibrio alginolyticus   Thermoanaerobacter pseudethanolicus   Arion vulgaris   Lentimonas   Sistrurus miliarius barbouri   Rhizobium leguminosarum bv. viciae Vc2   Gossypium robinsonii   Tremella   Citrobacter rodentium   Giardia intestinalis assemblage A   Laodelphax striatellus   Rhizobium leguminosarum bv. phaseoli CCGM1   Chlorocebus aethiops aethiops   Blattella germanica   Cyanobacterium stanieri   Ustilago maydis virus P4   Brassica oleracea var. capitata   Bacillus thuringiensis Bt407   Mycobacterium avium subsp. hominissuis   Influenza B virus (B/Memphis/13/2003)   Salmo salar   Aquilaria sinensis   Taraxacum sp.   Mycobacterium tuberculosis variant bovis BCG   Paulinella chromatophora   Streptococcus dysgalactiae subsp. equisimilis SK1249   Clarias gariepinus   Azospirillum brasilense FP2   Buddenbrockia plumatellae   Mus musculus musculus x Mus musculus castaneus   Hypotermes   Acidovorax citrulli   Tomato yellow leaf curl virus   Elizabethkingia meningoseptica   Marseillevirus   SARS bat coronavirus   Populus tomentosa   Escherichia coli HT115   Brucella melitensis   Serratia plymuthica   Rickettsia conorii str. Malish 7   Siphoviridae   Tenebrio molitor   Botrytis cinerea   Thalassiosira oceanica   Syntrophomonas wolfei   Echinococcus granulosus   Aerococcus urinae NBRC 15544 = CCUG 36881   Deinococcus deserti VCD115   Conus zonatus   Sarcoptes scabiei   Pomacea maculata   Arachis hypogaea   Methanosarcina acetivorans   Pseudoliparis swirei   Acromyrmex echinatior   Colpophyllia natans   Brassica oleracea var. gemmifera   Halobacterium salinarum R1   Formosa sp. Hel1_33_131   Pseudomonas fluorescens   HIV-1 vector pNL4-3   Fomitopsis pinicola   Thalassiosira pseudonana CCMP1335   Agkistrodon contortrix   Paracoccidioides lutzii Pb01   Myxobolus wulii   Natronomonas pharaonis DSM 2160   Olavius algarvensis sulfate-reducing endosymbiont   Buchnera aphidicola (Acyrthosiphon pisum)   Bacillus altitudinis   Beauveria bassiana CGMCC 7.34   Cupriavidus pinatubonensis JMP134   Anopheles culicifacies B   Candidatus Kuenenia stuttgartiensis   Human alphaherpesvirus 1   Vitis   Haloferax volcanii DS2   Bacillus subtilis subsp. subtilis   Mycoplasmopsis agalactiae   Candida albicans SC5314   Lupinus angustifolius   Eimeria acervulina   Erythrobacter sp. RAS19   Bungarus   Macaca nemestrina   Murine respirovirus   Momordica cochinchinensis   Plasmodium knowlesi strain H   Prevotella intermedia ATCC 25611 = DSM 20706   Cavia porcellus   Trypanosoma cruzi cruzi   Amphistegina lobifera   Mycoplasma feriruminatoris   Streptococcus pneumoniae R6   Enterococcus mundtii CRL35   Merluccius bilinearis   Aedes aegypti aegypti   Saccharomyces cerevisiae W303   Pseudomonas aeruginosa LESlike1   Escherichia coli   Salmonella enterica subsp. enterica serovar Untypable str. 83332   Naja mandalayensis   Human herpesvirus 2 strain 186   Lactococcus lactis subsp. lactis Il1403   Anaeromyces   Mollivirus sibericum   Medicago sativa subsp. x varia   Deinococcus radiodurans   Streptomyces sp. MBT84   Aepyceros melampus   Hymenolepis microstoma   Solanum peruvianum   Diaphorina citri   Myxococcus xanthus DZ2   Cervus nippon hortulorum   Pinus nigra   Camelus dromedarius   Fusarium oxysporum f. sp. conglutinans Fo5176   Aspergillus   Acidithiobacillus ferrooxidans ATCC 53993   Bordetella parapertussis 12822   Mytilus galloprovincialis   Myrmica ruginodis   Salmonella enterica subsp. enterica serovar Enteritidis str. EC20120200   Neisseria gonorrhoeae   Centruroides vittatus   Quercus ilex   Dolichospermum circinale AWQC310F   Didelphis aurita   Streptococcus pneumoniae SP14-BS69   Vairimorpha necatrix   Pseudovibrio sp. FO-BEG1   Candidatus Endoriftia persephone   Mycobacterium tuberculosis C StG4006   Sanghuangporus   Trifolium pratense   Bacillus thuringiensis serovar berliner ATCC 10792   Mytilus sp. CHGF4   Picrorhiza kurrooa   Klebsiella pneumoniae 342   Nicotiana langsdorffii   Xenopsylla cheopis   Vibrio harveyi   other sequences   Amycolatopsis   Fungi   Serendipita vermifera 'subsp. bescii'   Gynandropsis gynandra   Viola tricolor   Kluyveromyces lactis NRRL Y-1140   Ambystoma mexicanum   Cyclopes didactylus   Saccharomyces mikatae IFO 1815   Drosophila simulans   Cytophaga hutchinsonii   Varanus komodoensis   Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344   Saimiri boliviensis boliviensis   Potentilla saundersiana   Plasmodium berghei ANKA   Staphylococcus aureus subsp. aureus   Apteronotus leptorhynchus   Leptospermum scoparium   Trypanosoma cruzi marinkellei   Chaetodon lunulatus   Lutra lutra   Lactococcus lactis   Plasmodium falciparum V1   Cancer   Carassius gibelio   Helianthus annuus   Varroa destructor   Lithobius forficatus   Erythrobacter sp. HL-111   Rhizorhabdus wittichii   Pseudomonas phage EL   Halomonas sp. TD01   Roseburia intestinalis L1-82   Lactococcus lactis subsp. cremoris MG1363   Acinetobacter baumannii D1279779   Picea likiangensis var. rubescens   Cupiennius salei   Salmonella enterica subsp. enterica serovar Typhimurium str. SDT1291   Roseburia hominis A2-183   Populus tremula x Populus alba   Podospora anserina S mat+   Streptococcus equi subsp. equi   Emiliania huxleyi CCMP371   Catalpa fargesii   synthetic construct   Colobus guereza   Quercus robur   Simulium damnosum s.l. Me1   Pseudotsuga menziesii var. menziesii   Capreolus capreolus   Calicophoron daubneyi   Trichodesmium erythraeum IMS101   Kluyveromyces marxianus   Agrobacterium tumefaciens   Phikzvirus phiKZ   Mus musculus x Rattus norvegicus   Naja nigricincta nigricincta   Campylobacter fetus subsp. fetus 82-40   Manduca sexta   Panthera tigris   Nelumbo nucifera subsp. nucifera   Trichoderma sp. 1 YW-2011   Olavius algarvensis spirochete endosymbiont   Aedes albopictus   Faustovirus   Vicia faba   Dionaea muscipula   Francisella tularensis subsp. tularensis   Aspergillus versicolor   Sepiadarium austrinum   Crassostrea gigas   Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2   Broussonetia papyrifera   Rupicapra rupicapra   Acinetobacter nosocomialis   Strigamia maritima   Bacillus anthracis str. Sterne   Saturnispora dispora   Novosphingobium nitrogenifigens   Staphylococcus aureus subsp. aureus NN50   Acipenser transmontanus   Gorilla gorilla gorilla   Candidatus Methylomirabilis oxyfera   Streptomyces venezuelae   Colwellia psychrerythraea 34H   Neoporphyra haitanensis   Xanthomonas campestris pv. vesicatoria str. 85-10   Caldanaerobacter subterraneus subsp. tengcongensis MB4   Chlamydia trachomatis L2/434/Bu(i)   Escherichia coli K-12   Plasmodium coatneyi   Lonicera japonica   Aves   Streptomyces sp. MBT42   Musa acuminata x Musa textilis   biofilm metagenome   Giardia intestinalis   Ixodes ricinus   Oleidesulfovibrio alaskensis G20   Burkholderia dolosa AU0158   Streptomyces griseorubens   Gadus morhua   Cupriavidus metallidurans   Bacillus sp. 142311   mouse gut metagenome   Severe acute respiratory syndrome coronavirus 2   Meandrina meandrites   Xanthomonas oryzae pv. oryzae PXO99A   environmental samples   Apium graveolens   Rupicapra pyrenaica   Pomacea canaliculata   Acesta excavata   thiotrophic endosymbiont of Bathymodiolus azoricus (Menez Gwen)   Thermodesulfobium acidiphilum   Human herpesvirus 8 strain rKSHV.219   Pristhesancus sp. 00004635   West Nile virus   Amphimedon   Cicer arietinum   Didelphis virginiana   Malaclemys terrapin   Culex pipiens pipiens   Synechocystis sp. PCC 6803 substr. PCC-P   Manica rubida   Streptomyces scabiei 87.22   Lactobacillus johnsonii N6.2   Nicotiana benthamiana   Trichoplax sp. H2   Rhipicephalus sanguineus complex sp. ME-2011   Beauveria bassiana   Panopea generosa   Dictyostelium discoideum AX4   Lipomyces starkeyi   Butyrivibrio proteoclasticus B316   Capsaspora owczarzaki   Stenotrophomonas rhizophila   Scylla paramamosain   Cyclotella cryptica   Trichuris muris   Ciona intestinalis   Brachionus plicatilis   Nostoc sp. PCC 7120 = FACHB-418   Aspergillus aff. niger A2   Neospora caninum   Modiolus kurilensis   Trypanosoma cruzi strain Esmeraldo   Serpentes   Aspergillus terreus NIH2624   Mustela putorius furo   Allexis   Clavispora lusitaniae ATCC 42720   cf. Chlorella sp.   Staphylococcus haemolyticus   Pandanus amaryllifolius   Xanthomonas campestris   Bacillus amyloliquefaciens   Bacillus thuringiensis serovar kurstaki str. HD73   Alcaligenes faecalis   Trypanosoma dionisii   Lentilactobacillus kefiri   Entamoeba histolytica HM-1:IMSS-B   Triatoma dimidiata   Rickettsia slovaca 13-B   Fragaria x ananassa   Escherichia coli O157:H7 str. TW14359   Photobacterium profundum SS9   Roseburia inulinivorans DSM 16841   Olavius algarvensis   Medicago truncatula   Nicotiana glauca   Ovis canadensis mexicana   Palaemonetes sp. common grass shrimp associated circular virus   Schizosaccharomyces pombe   Nitrosomonas ureae   Gelatoporia subvermispora   Argulus foliaceus   Chlorella sp. SAG 211-18   Nothobranchius furzeri   Hypsiglena jani   Colobanthus quitensis   Francisella orientalis FNO12   Thermoplasma acidophilum DSM 1728   Arvicola   Nematostella vectensis   Synechocystis sp. PCC 6803 substr. GT-I   Synechococcus sp. BL107   methanotrophic endosymbiont of Bathymodiolus azoricus (Menez Gwen)   Marchantia polymorpha   Dactylorhiza   Betainfluenzavirus   Lactococcus phage   Murine leukemia virus isolates   Mycobacterium tuberculosis SP10   Trichomonas vaginalis G3   Streptococcus pyogenes STAB901   Human papillomavirus type 16   Strigomonas culicis   Legionella pneumophila   Proteus mirabilis HI4320   Euprymna scolopes   Brassica oleracea var. italica   Trypanosoma erneyi   Rhynchocyon petersi   Plasmodium yoelii yoelii 17XNL   Notamacropus eugenii   Equus asinus africanus   Podospora   Dengue virus   Staphylococcus aureus subsp. aureus USA300_TCH1516   Eucalyptus spp. mixed library   Pyricularia oryzae B157   Archaea   Staphylococcus lugdunensis   Tubastraea coccinea   Bothrops asper   Melopsittacus undulatus   Salmonella enterica subsp. enterica serovar Muenchen   Streptococcus sanguinis SK36   Trypanosoma brucei   Coprothermobacter proteolyticus   Corynebacterium diphtheriae NCTC 13129   Kuraishia capsulata   Alteromonas macleodii ATCC 27126   Anneissia japonica   Glossina morsitans   Boehmeria nivea   Tospovirus kiwifruit/YXW/2014   Trichoderma harzianum CBS 226.95   Mus musculus wagneri   Eubacterium limosum   Hendra virus horse/Australia/Hendra/1994   Paracoccus denitrificans PD1222   Influenza A virus (H1N1)   Cellvibrio japonicus Ueda107   Pachycladon cheesemanii   unclassified Marseilleviridae   Sistrurus catenatus   Pogona vitticeps   Herpesvirales   Tapirus terrestris   Macadamia   Persicaria minor   Phaseolus vulgaris   Pongo abelii   Chlorobaculum tepidum   Pimephales promelas   Rhizopus delemar   Acanthamoeba polyphaga   Harmonia axyridis   Methanospirillum hungatei JF-1   Candidatus Accumulibacter   Cyanophora paradoxa   Triticum aestivum   Candida parapsilosis   Rosa chinensis   Taeniopygia guttata   Delonix regia   Influenza A virus (A/Aichi/68/2007(H3N2))   Viola   Acanthoscurria geniculata   [Ruminococcus] gnavus ATCC 29149   wastewater metagenome   Fusarium graminearum PH-1   Pseudomonas entomophila L48   Sarcophilus harrisii   Phaeobacter sp. MED193   Craterostigmus tasmanianus   Acinetobacter baumannii 1656-2   Camelidae   Plasmodium sp. pBT9   Herbaspirillum seropedicae   Apis mellifera   Piper nigrum   Daucus carota subsp. sativus   Capra hircus   Hydrolagus colliei   Brucella   Plasmodium yoelii   Pangasianodon hypophthalmus   Streptococcus pyogenes ABC020006030   Eulimnogammarus vittatus   Giardia   Bodo saltans   Onchocerca lupi   Vaccinia virus WR   Gammarus pulex   Bivalvia   Candidatus Thiosymbion oneisti   HIV-1 M:G_PT919   Lontra canadensis   Inquilinus limosus   Staphylococcus xylosus   Nitrospira marina Nb-295   environmental samples   Paenibacillus polymyxa   Cancer irroratus   Fraxinus nigra   HBV genotype D   Chlorocebus aethiops   Xylocopa violacea   Bifidobacterium longum subsp. longum   prokaryotic environmental samples   Pythium sp. PV So7   Norwalk virus   Xenopus laevis   Balneola vulgaris   Magnetospirillum gryphiswaldense   Klebsiella pneumoniae   Staphylococcus aureus subsp. aureus str. Newman   Gossypium hirsutum   Naja oxiana   Fusarium oxysporum f. sp. lycopersici   Chenopodium quinoa   Pseudomonas aeruginosa PAK   soil bacterium 10G-05   Human coronavirus HKU1   Hypsizygus marmoreus   Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821   Acinetobacter baumannii AB307-0294   Triticum monococcum subsp. monococcum   Escherichia coli O157:H7 str. EDL933   Botrytis cinerea T4   Nitrospinae   Laxus oneistus   Phytophthora capsici LT1534   sediment metagenome   Aspergillus fumigatus var. fumigatus   Meleagris gallopavo   Mycobacterium avium subsp. paratuberculosis K-10   Chaetoceros sp.   Lactobacillus sp. Y10   Coffea arabica   Spirometra erinaceieuropaei   Nicotiana noctiflora   Secale cereale   Ictidomys tridecemlineatus   Pygoscelis adeliae   Histomonas meleagridis   Yersinia pestis CO92   Dreissena polymorpha   Mytilus edulis/galloprovincialis MCLGV-2007   Cecropia peltata   Lymnaea stagnalis   Breviatea   Neospora caninum Liverpool   Pseudomonas taiwanensis   Mycoplasmopsis bovis HB0801   Rhizobium cf. leguminosarum   Dinoroseobacter shibae DFL 12 = DSM 16493   Durusdinium trenchii   Clostridioides difficile 050-P50-2011   Clavibacter michiganensis subsp. michiganensis NCPPB 382   Pseudomonas sp. UK4   Babesia canis canis   [Ruminococcus] gnavus   Toxoplasma gondii type III   Dehalococcoides mccartyi CBDB1   Ophrys garganica   Selenomonas sputigena ATCC 35185   Macaca fascicularis   Formosa sp. Hel3_A1_48   Larimichthys crocea   Homo   Citrus hybrid cultivar   Penicilliopsis zonata   Norovirus Hu/GII.4/Saga4/2009/JP   Shigella sonnei 53G   Anisakis simplex   Passer domesticus domesticus   Acetobacterium wieringae   Human herpesvirus 5 strain Merlin   Sesamum indicum   marine plankton environmental sample   Rhodothermus marinus DSM 4252   Apostichopus japonicus   Ferrimicrobium acidiphilum DSM 19497   Acidiphilium cryptum JF-5   Mycoplasma gallisepticum S6   Solidesulfovibrio magneticus RS-1   Escherichia coli str. K-12 substr. W3110   Teleogryllus oceanicus   Lagenaria siceraria   Neurospora crassa OR74A   Prototheca zopfii   Malus domestica   Pachysolen tannophilus NRRL Y-2460   Ricinus communis   Geodermatophilus obscurus DSM 43160   Schizosaccharomyces pombe DM3650   Lentinus crinitus   Bacteroides caccae   Oenothera elata   Influenza A virus (A/New Caledonia/20-JY2/1999(H1N1))   Pseudoalteromonas flavipulchra NCIMB 2033 = ATCC BAA-314   Schlechtendalia chinensis   Bacteroides thetaiotaomicron   Anser cygnoides   Helicobacter pylori H13-1   Leishmania infantum   Burkholderia cenocepacia J2315   Morchella importuna   Cricetidae   Synechocystis sp. PCC 6803 substr. Kazusa   Bifidobacterium longum NCC2705   Limosilactobacillus fermentum CECT 5716   Conus geographus   Medicago sativa   Herpes simplex virus unknown type   Pseudomonas aeruginosa PA14-RN6   Panine betaherpesvirus 2   Entamoeba histolytica HM-1:IMSS-A   Equus caballus   Acipenser baerii x Acipenser schrenckii   Tropheryma whipplei TW08/27   Pedobacter sp.   Leishmania chagasi   Nephila clavipes   Desulfovibrio ferrophilus   Blumeria hordei DH14   Mariprofundus ferrooxydans   Staphylococcus saprophyticus   Francisella tularensis subsp. holarctica LVS   Cupriavidus basilensis   Ophrys x arachnitiformis subsp. archipelagi   Lasiodiplodia theobromae   Ursus arctos arctos   Vespula vulgaris   Globicatella sanguinis   Populus yunnanensis   Mycolicibacterium smegmatis   Streptococcus suis   Klebsiella pneumoniae ATCC BAA-2146   Shigella flexneri 2a str. 2457T   Myrmica rubra   Firmicutes   [Candida] auris   Paenibacillus polymyxa ATCC 842   Neisseria gonorrhoeae FA 1090   Cyberlindnera jadinii   Clostridium cellulovorans   Bacillus weihenstephanensis   Bothrops cotiara   Acanthoscurria rondoniae   Phytophthora infestans   Stichodactyla haddoni   Roseburia   Sordaria macrospora   Blumeria graminis f. sp. tritici   uncultured Desulfobacterium sp.   Limnobacter thiooxidans   Human herpesvirus 5 strain AD169   Brucella abortus S19   Tilletia indica   Bothrops brazili   Beta vulgaris   Fusobacterium nucleatum subsp. nucleatum ATCC 25586   Salmonella enterica subsp. enterica serovar Typhimurium str. A130   Serratia phage JS26   Streptomyces avidinii   Toxoplasma gondii GT1   Armoracia rusticana   Methanohalophilus   Cricetulus griseus   Ictalurus punctatus   Rhizobium sp. CIAT652   Pseudomonas aeruginosa LESB58   Saccharomyces cerevisiae   Picea abies   Actinoplanes sp. SE50/110   Cellulophaga baltica NN016038   Bothrops moojeni   Rhizobium favelukesii   Oscillatoriaceae cyanobacterium   Danaus plexippus   Plasmodium falciparum FcB1/Columbia   Sordaria macrospora k-hell   Eggerthella phage P3   Salmonella enterica subsp. enterica serovar Paratyphi A str. ATCC 9150   Architeuthis dux   Trichoderma reesei QM9414   Halobacterium salinarum   Cannabis   Mycobacterium tuberculosis H37Rv_2009   Leishmania tarentolae   Afrohybanthus enneaspermus   Phaeocystis antarctica   Nerodia clarkii   Haemophilus haemolyticus   Medicago truncatula var. truncatula   Rickettsia akari   Ovis aries musimon   Dryopteris affinis subsp. affinis   Caenorhabditis elegans   Avicennia officinalis   Ursus maritimus   Mycoplasma gallisepticum   Photobacterium phosphoreum   Synechococcus sp. PCC 7002   Rapana venosa   Acinetobacter baumannii ATCC 19606 = CIP 70.34 = JCM 6841   Zymoseptoria tritici IPO323   Leishmania tropica   Plasmodium falciparum D10   Nannospalax galili   Viruses   Mengo virus   Craterostigma plantagineum   Epstein-barr virus strain p3hr-1   Homo sapiens   Candida albicans 24C   Salmonella enterica subsp. enterica serovar Typhi str. CT18   Nepenthes x hookeriana   Saccharum sp.   Ecrobia ventrosa   Mycobacterium tuberculosis variant bovis BCG str. Moreau RDJ   Peromyscus eremicus   Bothrops insularis   Listeria monocytogenes   Python bivittatus   Pseudomonas sp. TDA1   Lactobacillus iners   Brucella abortus str. 2308 A   Aspergillus fumigatus CEA10   Citeromyces matritensis   Meyerozyma guilliermondii ATCC 6260   Serendipita vermifera MAFF 305830   Mylodon darwinii   Thalassiosira cf. oceanica   Bacteroides fragilis NCTC 9343   Candida tropicalis   Loxosceles intermedia   Sterolibacterium denitrificans   Chlamydia trachomatis   Veillonella parvula DSM 2008   Human herpesvirus 4 strain B95-8   rat gut metagenome   Candidatus Pelagibacter ubique   Serpentes sp. WLS21042014   Bartonella quintana JK 31   fungal sp. 5OL6-6PL1   Lacticaseibacillus rhamnosus   Stigmatella aurantiaca DW4/3-1   Myxobilatus gasterostei   Priestia megaterium DSM 319   Apis mellifera pomonella   Mycobacterium tuberculosis TKK-01-0032   Burkholderia ubonensis MSMB22   Taenia solium   mixed culture metagenome   Escherichia coli O26:H11   Paramoeba perurans   Clostridium saccharoperbutylacetonicum   Dehalococcoides mccartyi   H1N1 subtype   Riptortus pedestris   Fusarium oxysporum f. sp. lycopersici 4287   Saccharopolyspora erythraea   Acinetobacter sp. PM-14   Malassezia sympodialis   Mycoplasma pneumoniae M29   Methanobacterium   Apostasia shenzhenica   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456   Anopheles gambiae   Tremarctos ornatus   Struthio camelus   Plasmodium cynomolgi strain B   Human immunodeficiency virus 1   Xanthomonas citri pv. glycines str. 8ra   Pichia fermentans   Nicotiana sylvestris   Photobacterium carnosum   Vitis hybrid cultivar   Selaginella moellendorffii   Salmonella enterica subsp. enterica serovar Typhimurium   Pistacia vera   Helicobacter hepaticus   Leymus chinensis   Staphylococcus sp. KDM4   Human alphaherpesvirus 1 strain KOS   Sphingobium sp. AM   Dendrobium sp. XMW-2002-13   Corynebacterium ulcerans bv. belfanti   Nicotiana benavidesii   Schizophyllum commune H4-8   Leishmania sp. MHOM/IN/80/DD8   Megoura viciae   Acinetobacter baumannii AB5075   Nitrosomonas europaea ATCC 19718   Acipenser   Oryza barthii   Mus musculus   Nicotiana longiflora   Plasmodium vivax Sal-1   Lobaria pulmonaria   Pongo pygmaeus   Geobacillus stearothermophilus   Thermothelomyces thermophilus ATCC 42464   Gammarus fossarum   Babjeviella inositovora   Leishmania   Synechocystis sp. PCC 6803   Ferroplasma   Acanthamoeba castellanii   Nicotiana repanda   Rahnella aquatilis   Agaricus bisporus var. bisporus   Canis lupus x Canis lupus familiaris   Eucalyptus   Hyphomicrobium sp. MC8b   Musa ABB Group   Acheta domesticus   Panicum virgatum   Microcystis aeruginosa PCC 7806   Aedes aegypti   Naegleria gruberi   Citrus maxima   Clostridium cellulovorans 743B   Geobacillus kaustophilus HTA426   Chlamydia trachomatis 434/Bu   Mycoplasma suis KI3806   Mycobacterium tuberculosis str. Beijing/W BT1   Pseudomonas aeruginosa PAO1   Bartonella quintana   Euglena gracilis   Brassica carinata   Nevskia ramosa   Santalum album   Streptococcus mutans 19   Schistosoma mansoni   Luteibacter   Tupavirus   Cynodon dactylon   Pinctada maxima   Ebolavirus   Cuniculiplasma divulgatum   Acanthamoeba castellanii mimivirus   Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130   Burkholderia cenocepacia   Avena sativa   Pelea capreolus   Rhodobacter capsulatus SB 1003   Nostoc punctiforme PCC 73102   Dehalobacter restrictus   Pinus pinaster   Streptomyces lividans TK24   Pseudomonas syringae   Yersinia pseudotuberculosis   Odocoileus virginianus   Dickeya solani   Macrophomina phaseolina MS6   Phormidium sp. OSCR   Escherichia phage vB_EcoP_SU10   Candidatus Carsonella ruddii DC   Conus caracteristicus   Toxoplasma gondii ME49   Hypoxis hemerocallidea   Bifidobacterium kashiwanohense PV20-2   Manihot esculenta   Cricetulus barabensis   Leishmania donovani BPK282A1   Montastraea cavernosa   Rhizobium leguminosarum bv. viciae   Coronavirus PREDICT CoV-2   Anguilla anguilla   Tilletia controversa   Crotalus adamanteus   Haberlea rhodopensis   Danio rerio   Plasmodium falciparum 365.1   Dialister   Synechococcus elongatus   Campylobacter jejuni subsp. jejuni   Minona ileanae   Bacillus subtilis subsp. subtilis NCIB 3610 = ATCC 6051 = DSM 10   Bovine leukemia virus   Oryza sativa Indica Group   Taiwanofungus camphoratus   Helianthus tuberosus   Phytophthora pisi   Aliivibrio fischeri   Bacillus pumilus   Theobroma cacao   Angiostrongylus vasorum   Blastococcus saxobsidens   Moringa oleifera   Pseudomonas chlororaphis   Lactobacillus johnsonii   Nilaparvata lugens   Panax ginseng   Phycicoccus elongatus Lp2   Bacillus licheniformis   Bienertia sinuspersici   Rhizobium sp. Leaf68   Acetivibrio thermocellus   Hadrurus spadix   Burkholderia cenocepacia K56-2Valvano   Myzus persicae   Saccharum hybrid cultivar   Paracentrotus lividus   Vulpes lagopus   Aspergillus flavus var. flavus   Acidipropionibacterium acidipropionici   Leishmania major   Naja sagittifera   Sulfolobus islandicus LAL14/1   Giardia intestinalis assemblage B   Camponotus floridanus   Bifidobacterium pseudolongum   Mycobacterium avium subsp. paratuberculosis   Murine hepatitis virus strain A59   Mycobacterium marinum   Phascolarctos cinereus   Campylobacter concisus 13826   Desulfovibrio sp. G11   Spirochaeta sp. ELBA   Chelodina longicollis   Eremothecium gossypii   Shigella sonnei   Penaeus vannamei   unidentified marine bacterioplankton   Roseobacter denitrificans OCh 114   Candidatus Protochlamydia amoebophila UWE25   Coprococcus comes ATCC 27758   Cladocopium goreaui   Saccharomyces cf. cerevisiae   Aspergillus wentii   Avian infectious bronchitis virus (strain Beaudette CK)   Tyrannosaurus rex   Desmodesmus subspicatus   'Phaseolus vulgaris' phytoplasma   Bacteroides thetaiotaomicron VPI-5482   Hevea brasiliensis   Pseudomonas ogarae   Spongospora subterranea   Aspergillus flavus partitivirus 1   Metopolophium dirhodum   Delftia acidovorans SPH-1   Trypanosoma cruzi   Desulforapulum autotrophicum HRM2   Toxoplasma gondii CtCo5   Lactococcus cremoris   Saccharomycopsis capsularis   Brassica rapa   Mus   Fusarium oxysporum f. sp. cucumerinum   Russula atropurpurea   Triticum turgidum subsp. durum   Caprinae   [Candida] glabrata   Pseudo-nitzschia delicatissima   Synechocystis sp.   Streptococcus agalactiae FSL S3-026   Tuber magnatum   Geobacter sulfurreducens PCA   Human adenovirus 2   Trametes versicolor   Bacillus toyonensis BCT-7112   Corynebacterium glutamicum K051   Burkholderia pseudomallei K96243   Bursaphelenchus xylophilus   Plasmodium falciparum UGK 730.2   Francisella tularensis subsp. holarctica FSC200   Populus tremula   Ixodes scapularis   Caryophyllales   Lentinula edodes   Ascaris suum   Alligator sinensis   Listeria monocytogenes EGD-e   Salmonella enterica subsp. enterica serovar Typhimurium str. D23580   Geobacillus kaustophilus   human gut metagenome   Tomato spotted wilt orthotospovirus   Human alphaherpesvirus 1 strain 17   Vitis riparia   Vibrio cholerae O1 biovar El Tor str. N16961   Mycobacterium avium subsp. avium ATCC 25291   Rhodospirillum rubrum ATCC 11170   Escherichia coli str. K-12 substr. MG1655   Clostridium butyricum E4 str. BoNT E BL5262   Bacillus subtilis   Salmonella enterica subsp. enterica serovar Typhimurium str. ST1489   Saccharum hybrid cultivar SP80-3280   Nesocodon mauritianus   Canis dirus   Escherichia coli Nissle 1917   Eryx colubrinus loveridgei   Lactuca sativa   Pan troglodytes   Blastocystis   Oryzias latipes   Aspergillus flavus   Talaromyces funiculosus NCIM1228   Streptomyces sp. MC1   Tortispora caseinolytica   Influenza A virus (A/Wilson-Smith/1933(H1N1))   Juglans   Peterozyma xylosa   Amphibalanus amphitrite   Streptococcus pyogenes   Bemisia tabaci   Saiga tatarica   Botrytis cinerea B05.10   Bacillus cereus ATCC 14579   Melioribacter roseus P3M-2   Pituophis melanoleucus   Leptospira borgpetersenii serovar Hardjo   Campylobacter fetus subsp. fetus   uncultured marine microorganism   Brugia malayi   Leishmania major strain Friedlin   Cloning vector pEGFP-C1   Tetronarce californica   Sepia officinalis   Candidatus Methylomirabilis lanthanidiphila   Klebsiella pneumoniae LCT-KP289   Granulicatella adiacens ATCC 49175   Haemonchus contortus   Fusarium cf. oxysporum   Conus betulinus   Carya illinoinensis   Escherichia coli O157:NM   Listeria monocytogenes serotype 4b str. F2365   Lactococcus lactis subsp. cremoris UC509.9   Staphylococcus aureus subsp. aureus NCTC 8325   Salmo sp.   metagenomes   Mycobacterium tuberculosis variant bovis   Stephanorhinus   Acaryochloris marina MBIC11017   Trichodesmium   Acanthochromis polyacanthus   Glycine max x Glycine soja   Fraxinus mandshurica   Felis catus   Komagataella phaffii   Bacillus mycoides DSM 2048   Crithidia fasciculata   Enterobacter cloacae   Alligator mississippiensis   Sinorhizobium americanum   Passiflora edulis   Vibrio parahaemolyticus   Ruminiclostridium cellulolyticum H10   [Candida] glabrata CBS 138   Ascoidea rubescens   Hyalella azteca   Mycoplasma pneumoniae M129   Lolium arundinaceum   Escherichia coli O157:H7   Erysipelatoclostridium ramosum DSM 1402   Opsanus beta   Paradendryphiella salina   Myotis ricketti   Ehrlichia ruminantium str. Gardel   Trypanosoma brucei brucei   Paenibacillus amylolyticus   Lobomonas rostrata   Nicotiana gossei   hybrid   Pseudomonas composti   Strongyloides venezuelensis   Brachypodium distachyon   Saccharomyces cerevisiae YJM789   Bacillus cereus F837/76   Ensifer adhaerens   (Vitis vinifera x Vitis berlandieri) x Vitis berlandieri   Mesoplasma florum L1   Candidatus Accumulibacter phosphatis   Dehalococcoides mccartyi CG1   Physcomitrella   Crunoecia irrorata   Python molurus   Vibrio anguillarum   Leucoraja erinacea   Labeo rohita   Brassica napus   Paucilactobacillus suebicus   Ophiophagus hannah   Fibrobacter succinogenes subsp. succinogenes S85   Nicotiana rustica   Vertebrata   Cucumber mosaic virus   Clostridioides difficile   Mycobacterium tuberculosis K   Sulfolobus islandicus   Corynebacterium glutamicum ATCC 13032   Schizosaccharomyces pombe OY26   Piscirickettsia salmonis AUSTRAL-005   Nosema apis   Dirofilaria immitis   Halothiobacillus neapolitanus c2   Pseudomonas fluorescens PF5   Coprococcus eutactus   Clavibacter michiganensis subsp. nebraskensis NCPPB 2581   Shewanella oneidensis MR-1   Datura stramonium   Lingulodinium polyedra   Marchantia polymorpha subsp. ruderalis   Diplazium maximum   Andrias davidianus   Helicoverpa armigera   Mycobacterium tuberculosis SP22   Ursus deningeri   Legionella pneumophila subsp. pneumophila   Cedrela fissilis   Aspergillus fumigatus   Candidatus Thioglobus autotrophicus   Zygaena filipendulae   Vipera berus berus   Nitrosospira multiformis ATCC 25196   Rhodopseudomonas palustris CGA009   Chlamydia trachomatis D/UW-3/CX   Dicentrarchus labrax   Actinidia chinensis var. chinensis   Aeropyrum pernix K1   Gossypium   Cercopithecidae   Dehalococcoides mccartyi BTF08   Cucurbita maxima   Viscum album   Tetropium castaneum   Coelodonta antiquitatis   Ceuthophilus sp. Ceu_104_TX_San_Rattlesnake   Acyrthosiphon pisum   Capra ibex   Trypanosoma brucei brucei TREU927   Citrobacter freundii   Xanthomonas retroflexus   Naegleria fowleri   Chitinophaga pinensis   Myotis lucifugus   Aspergillus flavus FRR 342   Heterosigma akashiwo   Anopheles gambiae str. PEST   Acanthamoeba castellanii str. Neff   Nosema ceranae   Scutigera coleoptrata   Thermococcus eurythermalis   Serratia inhibens PRI-2C   Porphyromonas gingivalis   Dioscorea alata   Strongylocentrotus purpuratus   Aspergillus niger ATCC 13496   Yersinia enterocolitica   Synechococcus phage S-SSM7   Roseobacter sp. MED193   Oomycota   Vitis riparia x Vitis rupestris   Desulfofundulus kuznetsovii DSM 6115   Dokdonia sp. MED134   Bacillus pseudomycoides DSM 12442   Tropilaelaps mercedesae   Sporocytophaga myxococcoides   Phaeodactylum tricornutum CCAP 1055/1   Synechococcus phage syn9   Cowpox virus (Brighton Red)   Plasmodium berghei   Callinectes sapidus   Anaerotignum neopropionicum DSM 3847   Synechocystis sp. PCC 6803 substr. GT-S   Streptococcus pneumoniae TIGR4   Cronobacter sakazakii   Lachancea waltii NCYC 2644   Aeromonas hydrophila NJ-35   Cellulomonas gilvus ATCC 13127   Rhizophagus irregularis   Clostridium perfringens   Triatoma sordida   Bacillus cereus ATCC 10987   Toxoplasma gondii GAB3-2007-GAL-DOM9   Ictidomys tridecemlineatus arenicola   Brachylophosaurus canadensis   Ustilago maydis   Mycobacterium tuberculosis KZN 1435   Candidatus Margulisbacteria   Entamoeba histolytica HM-1:IMSS   Equus asinus   Perkinsus marinus   Mycoplasma pneumoniae M129-B7   Streptococcus pneumoniae   Chryseobacterium indologenes   Methanothermobacter thermautotrophicus   Gnathostoma spinigerum   Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S   Jaltomata herrerae   Musa   Tuber aestivum   Francisella tularensis subsp. holarctica   Acetomicrobium mobile   Aeromonas salmonicida subsp. salmonicida   Pseudomonas aeruginosa PAO1H2O   Burkholderia sp. Bk   Mastigamoeba balamuthi ATTC 30984   Euphorbia characias   Brevibacterium casei   Cairina moschata   unidentified chimeric sequence   Antidorcas marsupialis   Tequatrovirus T4   Caulobacter vibrioides NA1000   Influenza A virus (A/Viet Nam/1203/2004(H5N1))   Streptomyces roseifaciens   Cyanidioschyzon merolae   Mycobacterium sp. GN-10803   Leishmania braziliensis   Schistosoma haematobium   Bactrocera dorsalis   Alteromonadales   Arabidopsis   Pyrococcus abyssi   Aplysia californica   Butyrivibrio fibrisolvens   Musa acuminata subsp. acuminata   Heligmosomoides polygyrus bakeri   Ursus arctos   Echis carinatus   Paenibacillus pabuli   Desulfovibrio vulgaris str. Hildenborough   Microbiota   Aspergillus nidulans   Desulforamulus reducens MI-1   Pachysolen tannophilus   Litoricola marina   Octopodiformes   uncultured soil microorganism   Mycobacterium tuberculosis variant bovis AN5   Candidatus Paraburkholderia kirkii   Sphingobium chlorophenolicum   Mycobacterium tuberculosis H37RvAE   Fusarium sp.   Haemaphysalis longicornis   Neosciurus carolinensis   Magnaporthe sp. MG05   Mesorhizobium loti   Solanum lycopersicum   Chlorella vulgaris   Salmonella enterica subsp. enterica serovar Newport   Macaca fascicularis fascicularis   Thymallus thymallus   Leishmania mexicana MHOM/GT/2001/U1103   Lacticaseibacillus casei str. Zhang   Cuon alpinus   Aggregatibacter actinomycetemcomitans D7S-1   Lilium   Leishmania donovani   Anisakis simplex complex   Exiguobacterium sp. SH31   Oryza sativa   Pogostemon cablin   Salmonella enterica subsp. enterica serovar Typhimurium str. LT2   Viridiplantae   Caretta caretta x Chelonia mydas   Nicotiana tabacum   Burkholderia sp. 2332   Blautia producta ATCC 27340 = DSM 2950   Nephotettix cincticeps   Olavius algarvensis Delta 1 endosymbiont   Candida albicans   Syntrophobacter fumaroxidans MPOB   Pachycladon novaezelandiae   Coffea canephora   Gyrodactylus kobayashii   Ursus americanus   Thermus thermophilus HB8   Latrodectus hesperus   Liquorilactobacillus hordei   Anas platyrhynchos   Coprococcus sp. ART55/1   Cereibacter sphaeroides 2.4.1   Wolbachia pipientis wMelCS   Bacillus cereus AH187   Penicillium sp. B12   Klebsiella pneumoniae ATCC 43816   Methanoculleus sp. 10   Catenibacterium   Chlamydomonas reinhardtii CC3269   Human alphaherpesvirus 1 strain F   Helicobacter pylori J99   Drosophila melanogaster   Levilactobacillus brevis   Scolopendra morsitans   Equus hydruntinus   Aeromonas sp. enrichment culture clone AM2   Ampulex compressa   Piromyces sp.   Halorubrum lacusprofundi ATCC 49239   Corynebacterium diphtheriae   Crotalus horridus   Phytophthora capsici   Beauveria bassiana ARSEF 2860   Secale cereale x Triticum turgidum subsp. durum   Pseudomonas aeruginosa   Bordetella bronchiseptica   Influenza A virus   Bothrops jararaca   Streptococcus mutans UA159   Pseudotsuga menziesii   Microcebus murinus   Parasynechococcus marenigrum WH 8102   Kalanchoe fedtschenkoi   Schmidtea mediterranea   Orthopoxvirus   Gorilla gorilla   Dentex dentex   Nostoc sp. FB71   Lichtheimia corymbifera JMRC:FSU:9682   Influenza A virus (A/WSN/1933(H1N1))   Carnobacterium maltaromaticum   Andreprevotia sp. IGB-42   Staphylococcus aureus subsp. aureus USA300   Agkistrodon piscivorus   Chlamydomonas reinhardtii   Staphylococcus aureus   Spinacia oleracea   Acanthaster planci   Sorghum bicolor   Cervus elaphus kansuensis   Chinchilla lanigera   Dugesia japonica   Amphiporus lactifloreus   Yarrowia lipolytica   Micromonas commoda   Mycobacterium tuberculosis variant bovis str. Ravenel   Tribolium castaneum   Haloferax volcanii   Emiliania huxleyi virus 207   Centruroides hentzi   Lactobacillus   Streptomyces sp. EF-93   Oreochromis niloticus niloticus   Thermothelomyces heterothallicus   Penicillium oxalicum   Polypodium hydriforme   Heterorhabditis megidis   Sulfuritalea   Pseudodiploria clivosa   Campylobacter concisus UNSWCD   Dickeya dadantii subsp. dadantii   Clostridium   Nitrososphaera viennensis EN76   Galloanserae   Thermosynechococcus vestitus BP-1   Methermicoccus shengliensis DSM 18856   Dolichospermum circinale AWQC131C   Treponema   Prorocentrum donghaiense   Dinosauria   Bacteria   Mucilaginibacter   Klebsiella pneumoniae subsp. pneumoniae DSM 30104 = JCM 1662 = NBRC 14940   Ovis   Stappia stellulata DSM 5886   Dendroaspis angusticeps   Xanthomonas translucens   Clostridium autoethanogenum   Pachycladon fastigiatum   Tuber indicum   Bathymodiolus azoricus   Spiroplasma melliferum   Mycobacterium tuberculosis H37Rv   Alphainfluenzavirus   Alicycliphilus denitrificans BC   Coxiella-like endosymbiont of Rhipicephalus sanguineus complex   Ustilaginoidea virens   Methylocystis sp. SC2   Mycobacterium tuberculosis M24   Saccharomyces cerevisiae S288C   Coprothermobacter   Orbicella annularis   Tetrahymena thermophila SB210   Pseudomonas putida BIRD-1   Homo sapiens/Mus musculus xenograft   Human herpesvirus 4 type 1   unclassified Bacteria   Equidae   Plasmodium falciparum   Actinomycetospora chiangmaiensis DSM 45062   artificial sequences   Liberibacter endosymbiont of Diaphorina citri   Neisseria meningitidis FAM18   Bombus terrestris audax   Schistocephalus solidus   Prochlorococcus marinus subsp. pastoris str. CCMP1986   Dorea longicatena DSM 13814   Mustela sp.   Cellulophaga baltica 18   Sinorhizobium americanum CCGM7   Faecalibacterium prausnitzii SL3/3   Rhodotorula toruloides   Nicotiana clevelandii   Phormidium rubidum A09DM   Gallus gallus   Spodoptera frugiperda   Klebsiella variicola   Dasypogon diadema   Pseudomonas sp.   Papaver somniferum   Pyrococcus furiosus   Latilactobacillus curvatus   Asterias rubens   Cylindrospermopsis raciborskii CS-506   Myodes glareolus   Steinernema carpocapsae   Methanothermococcus thermolithotrophicus DSM 2095   freshwater sediment metagenome   Desmognathus ocoee   uncultured Clostridium sp.   Stenotrophomonas maltophilia   Myxobolus honghuensis   Legionella   Glycine soja   Aspergillus oryzae RIB40   Thermococcus gammatolerans EJ3   Enhydra lutris nereis   Lineus longissimus   Streptococcus pneumoniae D39   Acinetobacter baumannii ATCC 17978   Boiga irregularis   Cytomegalovirus   Carboxydothermus ferrireducens DSM 11255   Acidithiobacillus ferrooxidans   Algoriphagus marincola HL-49   Vaccinia virus   Vibrio cholerae   Yersinia pestis KIM D27   Legionella pneumophila str. Paris   Brucella anthropi ATCC 49188   Puccinellia tenuiflora   Cleome angustifolia   Thalassiosira pseudonana   Persea americana   Salmonella enterica subsp. enterica serovar Enteritidis str. P125109   Staphylococcus epidermidis   Microbacterium sp. LEw-1055   Ovis aries   Neisseria meningitidis MC58   Vibrio cholerae O1 str. VC91   Nicotiana x sanderae   Sitobion avenae   Trichinella britovi   Arabidopsis thaliana   Granulicella sp.   Phoenix dactylifera   Daktulosphaira vitifoliae   Prevotella ruminicola 23   Methylorubrum extorquens DM4   Olavius algarvensis Gamma 1 endosymbiont   Toxoplasma gondii   Enchytraeus crypticus   environmental samples   Sophora alopecuroides   Sinapis alba   Onchocerca volvulus   Lolium multiflorum   Nitrospira moscoviensis   Shigella flexneri   Pseudomonas fluorescens SBW25   Macaca mulatta   Pyrodictium delaneyi   Crassostrea hongkongensis   Aspergillus oryzae var. oryzae   Wolbachia endosymbiont of Culex quinquefasciatus Pel   Tepidanaerobacter acetatoxydans   Mycobacterium tuberculosis SP7   Syntrophus aciditrophicus   Gorilla   Schistosoma japonicum   Emiliania huxleyi   Rhodococcus jostii RHA1   Musa acuminata subsp. malaccensis   environmental samples   Sedum plumbizincicola   Clostridium phage c-st   Komagataella pastoris DSMZ 70382   Scorpaena plumieri   Micrurus tener   Trypanosoma   Salmonella enterica subsp. enterica serovar Typhimurium str. 14028s Wu   Lecanicillium fungicola var. fungicola   Rathayibacter toxicus   Bison   Dichocoenia stokesii   Tannerella forsythia   Qipengyuania flava   Babesia canis   Sturnus vulgaris   Plum pox virus   Aggregatibacter actinomycetemcomitans   Gallus   Synechococcus sp. WH 7803   Homo sapiens subsp. 'Denisova'   Bothrops jararacussu   Shigella dysenteriae   Staphylococcus sp. 1   Triticum turgidum   Klebsiella pneumoniae MGH 78578   Azumapecten farreri   Clostridium botulinum F str. Langeland   Human immunodeficiency virus type 1 3916-CRO   Vibrio campbellii ATCC BAA-1116   Vitis vinifera   Brucella abortus 2308   Dendrobium huoshanense   Saccharum hybrid cultivar x Sorghum bicolor   Pachycladon exile   Helicobacter pylori A45   Thermochaetoides thermophila   Ianthella basta   Trypanosoma rangeli SC58   Dictyostelia   Staphylococcus pseudintermedius   uncultured bacterium   Monilinia laxa   Colon   Citrus sinensis   Burkholderia thailandensis   Onchocerca ochengi   Helicobacter pylori E48   Wheat dwarf virus - [Taiyuan]   Oreochromis mossambicus   Listeria phage A118   Rhizobium leguminosarum bv. viciae 3841   Candidatus Riegeria   Bubalus bubalis   Listeria phage A500   Lingula anatina   Legionella pneumophila subsp. pneumophila str. Philadelphia 1   Camponotus fellah   Shewanella baltica   Paulownia fortunei   Aiptasia   Deltaproteobacteria bacterium RIFCSPLOWO2_12_FULL_50_11   Bacillus velezensis   Piaractus mesopotamicus   Pyrenochaeta sp.   Actinomycetia   Cowpox virus   microbial mat metagenome   Octopus vulgaris   Trypanosoma cruzi Dm28c   Fagopyrum esculentum   Oryctolagus cuniculus cuniculus   Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759   Scophthalmus maximus   Staphylococcus cohnii   glacier metagenome   Streptococcus thermophilus LMD-9   Philodryas patagoniensis   Haemophilus influenzae   Sepioloidea lineolata   Sinopodophyllum hexandrum   Lacrimispora saccharolytica   Candida dubliniensis CD36   Naja mossambica   Panagrolaimus   Podospora anserina   Hepatitis B virus   Clostridium botulinum A str. Hall   Musa AAB Group   Entamoeba histolytica   Nanger dama mhorr   Bacillus mycoides NBRC 101238 = DSM 11821   Coxsackievirus B3   Leishmania braziliensis MHOM/BR/75/M2904   Myzus persicae persicae   Pasteurella multocida   Renibacterium salmoninarum ATCC 33209   Paulownia   Cryptococcus neoformans var. grubii VNI   Taenia hydatigena   Avena strigosa   Nitrospirillum amazonense CBAmc   Microbacterium oxydans   Trypanosoma cruzi strain CL Brener   Pyrus x bretschneideri   Aspergillus niger CBS 513.88   Ganoderma lingzhi   Scheffersomyces stipitis   Aspergillus tubingensis   Acinetobacter baumannii   Human immunodeficiency virus   Quercus ilex subsp. ilex   Thraustochytrium sp. ATCC 26185   Soa   Aspergillus nidulans FGSC A4   Aspergillus nidulans TN02A3   Sulfurospirillum halorespirans DSM 13726   Pseudomonas pseudoalcaligenes   Leishmania infantum JPCM5   Fusarium oxysporum Fo47   Crocuta   Amaranthus tricolor   Citrus wilsonii   Klebsiella phage ST405-OXA48phi1.1   Nelumbo nucifera   Bacillus subtilis subsp. spizizenii ATCC 6633 = JCM 2499   Populus trichocarpa   Plasmodium vivax   Ralstonia pickettii   Lens culinaris   Acinetobacter sp.   Breviolum minutum   Serratia marcescens   Brucella abortus 104M   Capsicum annuum   Podospora anserina   Citrullus lanatus   Nostoc flagelliforme   Plasmodium yoelii yoelii   Platycladus orientalis   Staphylococcus aureus subsp. aureus COL   Chloromonas nivalis   Pteropus rodricensis   Influenza A virus (A/California/07-00002/2009(H1N1))   Coffea eugenioides   Tachaea chinensis   Methanosarcina mazei Go1   Asparagales   Protopterus dolloi   Ralstonia solanacearum GMI1000   Chlorocebus sabaeus   Vicia faba var. faba   Bacillariophyta   Aspergillus niger NRRL3   Frankia coriariae   Brachyspiraceae   Phaeodactylum tricornutum   Human gammaherpesvirus 4   Streptomyces sp.   Garcinia mangostana   Dichomitus squalens   Marmota monax   Coccinia grandis   Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044   bioreactor sludge metagenome   Limosilactobacillus mucosae LM1   Mycolicibacterium smegmatis MC2 155   Bordetella pertussis   Viola odorata   Elaeis guineensis   Ficus carica   Quercus petraea   Pseudomonas stutzeri   Ciona robusta   Stylophora pistillata   Bacillus cytotoxicus NVH 391-98   Tamias striatus   Staphylococcus aureus subsp. aureus MRSA252   Ctenopharyngodon idella   Listeria monocytogenes EGD   Salmonella bongori   Acinetobacter baylyi ADP1   Cutibacterium acnes SK137   Pinus radiata   Mycobacteroides abscessus ATCC 19977   Cryptococcus neoformans var. grubii H99S   Mesocricetus auratus   Elymus sibiricus   Mammut americanum   unidentified   marine sediment bacterium ISA-3146   Nitrososphaera viennensis   Pasteurella multocida subsp. multocida str. Pm70   Aspergillus niger   Oryctolagus cuniculus algirus   Clostridioides difficile 630   Bacillus subtilis subsp. subtilis str. 168   Vibrio vulnificus VV   Linnemannia elongata AG-77   Fusarium graminearum GZ3639   Meyerozyma guilliermondii   Lingulodinium   Daphnia magna   Lotus japonicus   Paraconiothyrium   Amphora coffeiformis   Bacillus cereus   Castor fiber   Coxiella burnetii RSA 493   Arcobacter   Amblyrhynchus cristatus   Pichia kudriavzevii   Canis lupus familiaris   Eukaryota   Saccharomyces cerevisiae EC1118   Carya cathayensis   Linum usitatissimum   Madurella mycetomatis   Ecrobia maritima   Equisetum arvense   Cryptosporidium andersoni   Desulfoluna spongiiphila   Tilletia laevis   Klebsiella pneumoniae UHKPC27   Anoplocephala perfoliata   Phytophthora infestans T30-4   Sylvicapra grimmia   Pseudoalteromonas sp. D41   Pogonomyrmex rugosus   Chromatiales bacterium OalgGamma1   Guillardia theta CCMP2712   Bradyrhizobium   unclassified Bacillarnavirus   Heliocidaris erythrogramma   Litoditis marina   Sus scrofa   Brassica oleracea   Thermus thermophilus   Conus striatus   Alternaria tomato   Ruminiclostridium papyrosolvens DSM 2782   Hadronyche infensa   Gasterosteus aculeatus   Malassezia sympodialis ATCC 42132   Burkholderia pseudomallei 1026b   Caballeronia mineralivorans   Klebsiella aerogenes   Candidatus Profftella armatura   Solanum tuberosum   Aspergillus fumigatus Af293   Tetranychus urticae   Olea europaea   Takifugu fasciatus   Ipomoea batatas   Corallium rubrum   Haemophilus influenzae Rd KW20   Helicobacter pylori   Streptococcus agalactiae   Azospirillum baldaniorum   Dictyostelium discoideum   Methanothrix   Carnobacterium divergens   Cenchrus americanus   Bordetella bronchiseptica RB50   Eucalyptus globulus   Eimeria tenella   unclassified Thermococcus   Synechococcus sp.   Neisseria meningitidis serogroup B   Salmonella enterica subsp. enterica serovar Enteritidis   Chlorella sp. FC2 IITG   Malassezia pachydermatis   Lactiplantibacillus plantarum JDM1   Aspergillus flavus NRRL3357   Tilletia caries   Hermarchus sp. HER2   Petunia x hybrida   Tetraponera aethiops   Human adenovirus 5   Rheum palmatum   Orbicella faveolata   Influenza A virus (A/California/07/2009(H1N1))   Anastrepha ludens   Bemisia cf. tabaci Middle East-Asia Minor 1   Thermococcus kodakarensis KOD1   Sphingobium indicum B90A   Dendroaspis polylepis polylepis   Saccharum spp. complex hybrid   Cajanus cajan   uncultured microorganism   Faecalibacterium prausnitzii   [Candida] boidinii   Akkermansia muciniphila ATCC BAA-835   Pseudomonas aeruginosa UCBPP-PA14   Platichthys flesus   Trichechus manatus   Micrurus fulvius   Corylus avellana   Cryptochiton stelleri   environmental samples   Teseptimavirus T7   Verticillium dahliae JR2   Toxoplasma gondii PRU   Gulo gulo   Lachancea kluyveri   Verticillium longisporum   Volvariella volvacea V23   Echinococcus ortleppi   Zea mays   soil bacterium TS1114R   Allochromatium vinosum DSM 180   Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088   Coxiella burnetii   Passer hispaniolensis   Oryza australiensis   Betacoronavirus sp.   Cryptococcus neoformans var. grubii H99   Mycobacterium tuberculosis SP13   Capsicum frutescens   Bordetella parapertussis   Oenothera glazioviana   Drosophila mauritiana   Naja naja   Toxoplasma gondii VEG   Tarenaya hassleriana   Euterpe oleracea   Leptospira interrogans   Parasteatoda tepidariorum   Acinetobacter sp. SA01   Halohasta litchfieldiae   Candida parapsilosis CDC317   Nepenthes ampullaria   uncultured Phormidium sp.   albimanus section   Cylindrospermopsis raciborskii CS-509   Staphylococcus lugdunensis N920143   Zymomonas mobilis   Bombus terrestris   Mycoplasma pneumoniae   Pseudomonas putida F1   Loxodonta africana   Gammarus roeselii   Brassica oleracea var. alboglabra   Naegleria sp. NGES2   Exidia glandulosa HHB12029   Plasmodium falciparum 58.1   Amblyomma americanum   Pseudomonas syringae pv. syringae   Clostridioides difficile ATCC 43255   Neocallimastix sp. G-1   Candidatus Glomeribacter   Dunaliella salina   Sorangium cellulosum So ce56   Borreliella burgdorferi B31   Salmonella enterica subsp. enterica serovar Typhimurium str. 5579   Lactobacillus delbrueckii   Bicyclus anynana   Mycobacterium tuberculosis LAM7   Mammalia   Campylobacter jejuni   Staphylococcus aureus subsp. aureus USA300_FPR3757   Hediste diversicolor   Channa striata   Bacillus amyloliquefaciens DSM 7 = ATCC 23350   Mycoplasma pneumoniae 19294   Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819   Streptomyces coelicolor A3(2)   Enterococcus faecium   Plethodon shermani   Amycolatopsis mediterranei S699   Prochlorococcus marinus str. MIT 9313   Corynebacterium diphtheriae bv. mitis str. ISS 3319   Paracoccus denitrificans   Nicotiana maritima   Frankia alni   Mycoplasma hominis ATCC 23114   Martes martes   Mahonia   Enterococcus faecium DO   Enterococcus faecalis   Jatropha curcas   Lysiphlebus fabarum   Hippoglossus hippoglossus   Neptuniibacter caesariensis   Halomonas sp. HL-48   Oncorhynchus mykiss   Tetrastichus   Norovirus Hu/GII.4/MI001/2011/USA   Fusarium culmorum   Nostoc sp.   Sphingomonas sp. Leaf257   Tritrichomonas foetus   Glycine max   environmental samples   Lacticaseibacillus rhamnosus GG   Streptococcus pyogenes M1 GAS   Schizosaccharomyces pombe 972h-   Tetrahymena thermophila CU428   Toxoplasma gondii RH   Clematis chinensis   Bos taurus   Oncorhynchus tshawytscha   Tetrahymena thermophila   Malassezia furfur   Clostridium butyricum DSM 10702   Leishmania mexicana   Rhizoctonia solani AG-8 WAC10335   Daboia russelii   Physalis angulata   Candidatus Nitrospira inopinata   Bacteroides sp. 1_1_11   Saccharomyces cerevisiae BY4741   Vibrio fluvialis   Populus tremula x Populus tremuloides   Nicotiana glutinosa   Bombyx mori   Pleuromamma xiphias   Alces alces   Ornithodoros moubata   Peniophora incarnata   Oryctolagus sp. 'Rabbit_OD'   Acholeplasma laidlawii PG-8A   Sulfurospirillum multivorans DSM 12446   Betaproteobacteria bacterium RIFCSPLOWO2_02_64_14   Vulpes vulpes   Klebsiella pneumoniae BIDMC 40   Tursiops truncatus   Neisseria meningitidis   Thalassiosira oceanica CCMP1005   Physcomitrium patens   Wolbachia endosymbiont of Onchocerca volvulus str. Cameroon   Nicotiana alata   Streptococcus uberis   Acropora digitifera   Clostridia   Yersinia pestis   Periplaneta americana   Aspergillus brasiliensis   Wolbachia sp. wMelPop   Prochlorococcus marinus str. MIT 9312   Afipia carboxidovorans   Eudiplozoon nipponicum   wood decay metagenome   Bacillus thuringiensis   Gigantopelta aegis   Leishmania donovani Ld 2001   Chroococcidiopsis thermalis PCC 7203   Haliotis discus hannai   Coccidioides posadasii str. Silveira   Bradyrhizobium japonicum   Thermochaetoides thermophila DSM 1495   Hepatitis C virus genotype 1   Mrakia psychrophila   Mammuthus sp.   Bordetella pertussis Tohama I   Rhodnius prolixus   Nakazawaea wickerhamii   Ailuropoda melanoleuca   rhizosphere soil bacteria ensemble   Castor canadensis   Cytomegalovirus sp.   Crocosphaera subtropica ATCC 51142   Knufia petricola   Liquorilactobacillus nagelii   Riftia pachyptila   Prevotella bryantii B14   Micrococcus luteus   Rousettus aegyptiacus   Synechococcus elongatus PCC 7942 = FACHB-805   Aspergillus carbonarius ITEM 5010   Roseibaca calidilacus   Mycobacterium avium 100   Musa acuminata AAA Group   Telmatactis   Lolium perenne subsp. perenne   Xanthomonas campestris pv. campestris str. B100   Pseudomonas aeruginosa PA14   Naja pallida   Skeletonema dohrnii   Stylosanthes guianensis   Oenococcus oeni   Streptococcus mutans serotype C   Sorghum bicolor x Saccharum hybrid cultivar   Panthera leo   Apis mellifera ligustica   Microcystis aeruginosa   Zoanthus sp.   Hippopotamus amphibius   Prunus avium   Arbacia punctulata   Porphyromonas gingivalis ATCC 33277   Planctopirus limnophila DSM 3776   Ornithodoros erraticus   Acinetobacter baumannii AB_TG2631   Deinococcus radiodurans R1   Lathyrus sativus   Tannerella forsythia 92A2   Aedes aegypti densovirus   Fasciola hepatica   Botryococcus braunii   Sparus aurata   Erysipelothrix rhusiopathiae   Canis lupus   gut metagenome   Equus sp.   Quercus   Candida tropicalis MYA-3404   Leptospirillum   Komagataeibacter europaeus   Agrostis stolonifera   Tepidimicrobium xylanilyticum   Palaemon carinicauda   Lagomorpha   Streptococcus thermophilus   Plasmodium falciparum Dd2   Hippophae rhamnoides   Frankia alni ACN14a   Anaerococcus hydrogenalis DSM 7454   Peromyscus leucopus   Drosophila montana   Agaricus bisporus   Bradyrhizobium diazoefficiens USDA 110   Saccharolobus solfataricus   Sulfolobus acidocaldarius   Chlamydia trachomatis L2/434/Bu(f)   Hominidae   Carica papaya   Amblyomma sculptum   Ruegeria pomeroyi   Neomegalonema perideroedes   Crustacea   Flavobacterium columnare   Ectocarpus siliculosus   Bithynia siamensis goniomphalos   Opisthorchis viverrini   Viola inconspicua   Capsicum annuum var. annuum   Rhinocerotidae   Filifactor alocis   Klebsiella pneumoniae JH1   Moraxella catarrhalis   Muvirus mu   Trichomonas vaginalis   Tuber melanosporum Mel28   Myxococcus xanthus DK 1622   Klebsiella variicola At-22   Desmodus rotundus   Saccostrea glomerata   Leuconostoc gelidum subsp. gasicomitatum   Giardia lamblia ATCC 50803   Cupriavidus necator N-1   Daphnia   Mammuthus primigenius   Paramecium tetraurelia   Mycobacteroides abscessus   Hordeum vulgare   Viola tricolor subsp. tricolor   Poterioochromonas malhamensis   Noccaea caerulescens   human metagenome   Nannochloropsis oceanica strain IMET1   Dimocarpus longan   Synechococcus cyanophage syn   Thelohanellus kitauei   Naja ashei   Arachis hypogaea var. vulgaris   Trichomonas gallinae   Clostridioides difficile str. A-027   Brochothrix thermosphacta   Francisella tularensis subsp. novicida U112   Murine leukemia virus   Ictalurid herpesvirus 1   Morganella   Nicotiana quadrivalvis   Moneuplotes crassus   Saccharina japonica   Halomonas sp.   Anaerostipes caccae L1-92   Japanese encephalitis virus   Pongo sp.   Cyanistes caeruleus   Norovirus   Spheniscus demersus   Rattus norvegicus   Biomphalaria glabrata  

TISSUE(S): Brain, Spinal Cord, Cell Culture, Hippocampus

SUBMITTER: Miguel Prado  

LAB HEAD: Daniel Finley

PROVIDER: PXD021991 | Pride | 2021-01-20

REPOSITORIES: Pride

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Publications


Familial neurodegenerative diseases commonly involve mutations that result in either aberrant proteins or dysfunctional components of the proteolytic machinery that act on aberrant proteins. UBQLN2 is a ubiquitin receptor of the UBL/UBA family that binds the proteasome through its ubiquitin-like domain and is thought to deliver ubiquitinated proteins to proteasomes for degradation. UBQLN2 mutations result in familial amyotrophic lateral sclerosis (ALS)/frontotemporal dementia in humans through a  ...[more]

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