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Chromophobe renal cell carcinoma versus renal oncocytoma: a proteomic approach

ABSTRACT: The proteome of clinical tissue samples diagnosed with chromophobe renal cell carcinomas (chRCC) and renal oncocytomas (RO) were evaluated to establish a potential discriminative biomarker panel of proteins for these two tumors subtypes.

INSTRUMENT(S): impact HD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

DISEASE(S): Chromophobe Renal Cell Carcinoma,Renal Oncocytoma

SUBMITTER: Hugo M. Santos

LAB HEAD: Hugo M. Santos

PROVIDER: PXD022018 | Pride | 2024-01-26

REPOSITORIES: Pride

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			Action	DRS
	15_RCC_raw_data.zip	Other
	andromeda.zip	Other
	txt.zip	Other

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Publications

Proteomic analysis of chromophobe renal cell carcinoma and benign renal oncocytoma biopsies reveals shared metabolic dysregulation.

Carvalho Luis B LB Jorge Susana S López-Fernández Hugo H Lodeiro Carlos C Dhir Rajiv R Campos Pinheiro Luis L Medeiros Mariana M Santos Hugo M HM Capelo José L JL

Clinical proteomics 20231128 1

<h4>Background</h4>This study investigates the proteomic landscapes of chromophobe renal cell carcinoma (chRCC) and renal oncocytomas (RO), two subtypes of renal cell carcinoma that together account for approximately 10% of all renal tumors. Despite their histological similarities and shared origins, chRCC is a malignant tumor necessitating aggressive intervention, while RO, a benign growth, is often subject to overtreatment due to difficulties in accurate differentiation.<h4>Methods</h4>We cond ...[more]

PMID: 38017382

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Proteome profilling of chromophobe renal cell carcinomas

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NCAM1: A Novel Autoantigen in Membranous Lupus Nephritis

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Expression data from human renal allograft biopsies to investigate renal transplant rejection and failure

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Detection of tetraploidization in chromophobe renal cell carcinoma: insights and pitfalls [Agilent CGH]

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Genotyping and copy number analysis of human renal epithelial neoplasms

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proteome profilling of chromophobe renal cell carcinomas

Project description:LC-MS/MS based proteomics study of chromophobe renal cell carcinomas versus the adjacent healthy kidney tissues, ten patients included.

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